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BIOSTATISTICS
Year : 2011  |  Volume : 2  |  Issue : 3  |  Page : 109-112

Intention-to-treat concept: A review

Sandeep K Gupta
Clinical Pharmacologist, Gurgaon, India

Date of Web Publication27-Jul-2011

Correspondence Address:
Sandeep K Gupta
J-1044, First Floor, Palam Vihar, Gurgaon - 122 001, Haryana
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2229-3485.83221

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   Abstract 

Randomized controlled trials often suffer from two major complications, i.e., noncompliance and missing outcomes. One potential solution to this problem is a statistical concept called intention-to-treat (ITT) analysis. ITT analysis includes every subject who is randomized according to randomized treatment assignment. It ignores noncompliance, protocol deviations, withdrawal, and anything that happens after randomization. ITT analysis maintains prognostic balance generated from the original random treatment allocation. In ITT analysis, estimate of treatment effect is generally conservative. A better application of the ITT approach is possible if complete outcome data are available for all randomized subjects. Per-protocol population is defined as a subset of the ITT population who completed the study without any major protocol violations.

Keywords: Intention-to-treat analysis, per-protocol analysis, randomized controlled trials


How to cite this article:
Gupta SK. Intention-to-treat concept: A review. Perspect Clin Res 2011;2:109-12

How to cite this URL:
Gupta SK. Intention-to-treat concept: A review. Perspect Clin Res [serial online] 2011 [cited 2018 Dec 16];2:109-12. Available from: http://www.picronline.org/text.asp?2011/2/3/109/83221


   Introduction Top


Randomized controlled trials (RCTs) often suffer from two major complications, i.e., noncompliance and missing outcomes. One potential solution to this problem is a statistical concept called intention-to-treat (ITT) concept. The objective of this article is to give a basic understanding of the ITT concept to the beginners in the field of clinical research. With this objective in mind, this article will review the ITT principle, with special emphasis on need and application of this concept and its pros and cons.


   Definition of ITT Concept Top


According to Fisher et al. (1990), the ITT analysis includes all randomized patients in the groups to which they were randomly assigned, regardless of their adherence with the entry criteria, regardless of the treatment they actually received, and regardless of subsequent withdrawal from treatment or deviation from the protocol. [1]

In other words, ITT analysis includes every subject who is randomized according to randomized treatment assignment. It ignores noncompliance, protocol deviations, withdrawal, and anything that happens after randomization. [2],[3],[4],[5] ITT analysis is usually described as "once randomized, always analyzed". [6],[7]

ITT analysis avoids overoptimistic estimates of the efficacy of an intervention resulting from the removal of non-compliers by accepting that noncompliance and protocol deviations are likely to occur in actual clinical practice. [4]


   Need for Such a Population Top


RCTs are the ideal design in assessing the efficacy and safety of medicine. In an RCT, the study subjects is randomly allocated to receive one of the treatments under study after assessment of eligibility but before the intervention is administered. Randomization in clinical trials reduces bias. The purpose of the RCT is to ensure that the groups differ only with respect to the interventions being compared. [8]

In an ideal scenario, every subject enrolled in RCT would follow instructions and complete their allocated treatment as described in the protocol and thus contribute data which were complete in all respects. [9] But unfortunately, one practical problem that investigators usually come across in RCT is that subjects do not always follow instructions. Moreover, in some studies, drop out of the subjects is a problem. Hence, RCTs often suffer from two major complications, i.e., noncompliance and missing outcomes. One potential solution to this problem is a statistical concept called ITT analysis. [10],[11]


   Pros of Using ITT Analysis Top


ITT is better regarded as a complete trial strategy for design, conduct and analysis rather than as an approach to analysis alone. [9],[12] Full reporting of any deviations from random allocation and missing response is essential in the assessment of the necessity and appropriateness of an ITT approach, as emphasized in the Consolidated Standards of Reporting Trials (CONSORT) guidelines on the reporting of RCTs. [12] The CONSORT statement for improving the quality of reports of RCTs states that number of participants in each group should be analyzed by "intention-to-treat" principle. [13]

ITT analysis reflects the practical clinical scenario because it admits noncompliance and protocol deviations. ITT analysis maintains prognostic balance generated from the original random treatment allocation. It gives an unbiased estimate of treatment effect. [3],[4],[14] If noncompliant subjects and dropouts are excluded from the final analysis, it might create important prognostic differences among treatment groups. Moreover, subjects may be noncompliant or may drop out from the study due to their response of treatment. [3]

ITT analysis preserves the sample size because if noncompliant subjects and dropouts are excluded from the final analysis, it might significantly reduce the sample size, leading to reduced statistical power. [3]

ITT analysis limits inferences based on arbitrary or ad hoc subgroups of patients in the trial and emphasizes greater accountability for all patients enrolled in the study. Also, it minimizes type I error due to cautious approach and allows for the greatest generalizability. [15]


   Cons of Using ITT Analysis Top


Many arguments against ITT analysis appear valid. To begin with, if a subject who actually did not receive any treatment is included as a subject who received treatment, then it indicates very little about the efficacy of the treatment. In ITT analysis, estimate of treatment effect is generally conservative because of dilution due to noncompliance. Also, heterogeneity might be introduced if noncompliants, dropouts and compliant subjects are mixed together in the final analysis. Moreover, end-point data will differ markedly among noncompliant, dropouts and compliant subjects, and interpretation might become difficult if a large proportion of participants cross over to opposite treatment arms. [3],[4],[12],[16],[17] ITT analysis has been criticized for being too cautious and thus being more susceptible to type II error. [12],[15]


   Who should use ITT? Top


A better application of the ITT approach is possible if complete outcome data are available for all randomized subjects. Care must always be taken to minimize missing responses and to continue to follow up those who withdraw from treatment. [4],[18],[19] Anyone who follows these principles intelligently and has a vision to minimize bias should not worry further about "intention to treat". [9] However, in most cases, missing data could also be dealt by using the last observation carried forward (LOCF) method, whereby the last available measurement for each individual at the time point prior to withdrawal from the study is retained in the analysis. [20],[21]

US Food and Drug Administration (FDA) guidelines for "The Format and Content of the Clinical and Statistical Sections of Applications" state that as a general rule, even if the applicant's preferred analysis is based on a reduced subset of the patients with data, there should be an additional "intent-to-treat" analysis using all randomized patients. The FDA guideline further explains that the results of a clinical trial should be assessed not only for the subset of patients who completed the study, but also for the entire patient population randomized (the ITT analysis). [22],[23]

Committee for Proprietary Medicinal Products (CPMP) note for guidance "Biostatistical Methodology in Clinical Trials for Marketing Authorisations for Medicinal Products" states that decisions concerning the analysis population should be guided by the principles underlying the "intention-to-treat" and the "per-protocol" strategies. When the ITT and per-protocol (PP) analyses come to essentially the same conclusions, confidence in the study results is increased. [22],[24]

The International Conference on Harmonisation (ICH) E9 guideline on "Statistical Principles for Clinical Trials" uses the term "full analysis set" to describe the analysis set which is as complete as possible and as close as possible to the ITT ideal of including all randomized subjects. [22],[25]

One of the alternatives of ITT analysis is the PP analysis. It is defined as a subset of the ITT population who completed the study without any major protocol violations. [26] PP analyses exclude all protocol violators, including anyone who did not adhere to treatment, switched groups, or missed measurements. [27] ITT tends to make the two treatments look similar, whereas the PP removes patients who do not complete treatment and is more able to reflect treatment differences. [28]

CPMP guideline states that for a superiority trial, the ITT analysis should be considered primary and the PP supportive. [29] It is often argued that the ITT analysis tends to dilute the treatment difference of interest. [30] Whereas the importance of the ITT population analysis in superiority designs has been well accepted, however there is no consensus about its role in non-inferiority trials. [31]

It has been argued that protocol violations and poorly conducted trials may cause the results obtained from two different treatment groups to appear similar. Hence, ITT analysis alone is not preferred for noninferiority trial. A possible alternative is to conduct the PP analysis where only subjects meeting the inclusion criteria are considered. But the conservative effect of the PP analysis on noninferiority and equivalence trials has not been thoroughly explored. Therefore, it has been suggested that noninferiority should be concluded only if both ITT and PP analyses permit that. [28],[31],[32],[33],[34],[35],[36] CPMP guideline states that in a noninferiority trial, the full analysis set based on the ITT principle and the PP analysis set have equal importance and their use should lead to similar conclusions for a robust interpretation. [29]


   Modified ITT Concept Top


It is a subset of the ITT population and allows the exclusion of some randomized subjects in a justified way (such as patients who were deemed ineligible after randomization or certain patients who never started treatment). However, the definition given to the modified ITT (mITT) in randomized controlled trial has been found to be irregular and arbitrary because there is a lack of consistent guidelines for its application. The mITT analysis allows a subjective approach in entry criteria, which may lead to confusion, inaccurate results and bias. [27],[37],[38] It is mostly used in anti-infective trials where multiple mITT populations can be defined for a single study such as clinical mITT and microbiological mITT. [39],[40]


   Summary and Conclusion Top


One practical problem that investigators usually come across in RCT is that subjects do not always follow instructions. Moreover, in some studies, drop out of the subjects is a problem. Hence, RCT often suffers from two major complications, i.e., noncompliance and missing outcomes. One potential solution to this problem is a statistical concept called ITT analysis. ITT analysis includes every subject who is randomized according to randomized treatment assignment. It ignores noncompliance, protocol deviations, withdrawal, and anything that happens after randomization. ITT analysis is usually described as "once randomized, always analyzed". But in ITT analysis, estimate of treatment effect is generally conservative because of dilution due to noncompliance. Also, heterogeneity might be introduced if noncompliants, dropouts and compliant subjects are mixed together in the final analysis. Moreover, end-point data will differ markedly among noncompliant, dropouts and compliant subjects, and interpretation might become difficult if a large proportion of participants cross over to opposite treatment arms. A better application of the ITT approach is possible if complete outcome data are available for all randomized subjects. Care must always be taken to minimize missing responses and to continue to follow up those who withdraw from treatment. Anyone who follows these principles intelligently and has a vision to minimize bias should not worry further about "intention to treat".


   Acknowledgement Top


I gratefully acknowledge the help of anonymous reviewers for helpful comments and suggestions.


   Disclaimer Top


The views and opinions expressed in this article are those of the author and do not necessarily reflect the official policy or position of his employer.

 
   References Top

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32 A Randomised Controlled Trial of a Brief Online Mindfulness-Based Intervention in a Non-clinical Population: Replication and Extension
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33 Motivational Interviewing Case Management (MICM) for Persons on Probation or Parole Entering Sober Living Houses
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Criminal Justice and Behavior. 2018; 45(11): 1634
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34 A pilot randomized controlled trial on the impact of text messaging check-ins and a web-based asthma action plan versus a written action plan on asthma exacerbations
Iraj Poureslami,Jessica Shum,Richard T. Lester,Hamid Tavakoli,Delbert R. Dorscheid,J. Mark FitzGerald
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35 Effect of a Mobile Phone Intervention on Quitting Smoking in a Young Adult Population of Smokers: Randomized Controlled Trial
Neill Bruce Baskerville,Laura Louise Struik,Godefroy Emmanuel Guindon,Cameron D Norman,Robyn Whittaker,Catherine Burns,David Hammond,Darly Dash,K Stephen Brown
JMIR mHealth and uHealth. 2018; 6(10): e10893
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N I Cherny,U Dafni,M Piccart,N J Latino,J-Y Douillard,J Bogaerts,D Karlis,P Zygoura,G Pentheroudakis,J Tabernero,C Zielinski,E G E de Vries
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37 Fecal transplantation for treatment of inflammatory bowel disease
Aamer Imdad,Maribeth R Nicholson,Emily E Tanner-Smith,Joseph P Zackular,Oscar G Gomez-Duarte,Dawn B Beaulieu,Sari Acra
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38 Memory Strategy Training in Older Adults with Subjective Memory Complaints: A Randomized Controlled Trial
Nikita L. Frankenmolen,Eduard J. Overdorp,Luciano Fasotti,Jurgen A.H.R. Claassen,Roy P.C. Kessels,Joukje M. Oosterman
Journal of the International Neuropsychological Society. 2018; 24(10): 1110
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39 Does walking protect against decline in cognitive functioning among breast cancer patients undergoing chemotherapy? Results from a small randomised controlled trial
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PLOS ONE. 2018; 13(11): e0206874
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40 Reaching rural veterans: a new mechanism to connect rural, low-income US Veterans with resources and improve food security
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41 A Pilot RCT Investigating the Effects of Targeted Compression on Athletes With Pelvic/Groin Pain
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42 The Effects of Mindfulness Meditation on Hope and Stress
Ricky T. Munoz,Steve Hoppes,Chan M. Hellman,Kara L. Brunk,Jedidiah E. Bragg,Carissa Cummins
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43 Modifying the Impact of Eveningness Chronotype (‘Night-Owls’) in Youth: A Randomized Controlled Trial
Allison G. Harvey,Kerrie Hein,Michael Dolsen,Lu Dong,Sophia Rabe-Hesketh,Nicole B. Gumport,Jennifer Kanady,James K. Wyatt,Stephen P. Hinshaw,Jennifer S. Silk,Rita L. Smith,Monique A. Thompson,Nancee Zannone,Daniel Jin Blum
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44 The Short Run Impact of Penalty Rate Cuts on Employment Outcomes in Retail and Hospitality Sectors in Australia
Martin OæBrien,Raymond Markey,Eduardo Pol
Economic Papers: A journal of applied economics and policy. 2018;
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45 Review: Yoga and mindfulness for youth with autism spectrum disorder: review of the current evidence
Randye J. Semple
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46 Increasing influenza vaccine uptake in children: A randomised controlled trial
Karene Hoi Ting Yeung,Marie Tarrant,Kate Ching Ching Chan,Wing Hung Tam,E. Anthony S. Nelson
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47 Effectiveness of digital resuscitation training in improving knowledge and skills: A systematic review and meta-analysis of randomised controlled trials
Ying Lau,Raphael Song Sue Nyoe,Suei Nee Wong,Zulkarnain Bin Ab Hamid,Benjamin Sieu-Hon Leong,Siew Tiang Lau
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48 Does providing inmates with education improve postrelease outcomes? A meta-analysis of correctional education programs in the United States
Robert Bozick,Jennifer Steele,Lois Davis,Susan Turner
Journal of Experimental Criminology. 2018;
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49 A randomized controlled trial of orthodontist-based brief advice to prevent child obesity
Melbourne F. Hovell,Katharine E. Schmitz,Sandy Liles,Kristi Robusto,C. Richard Hofstetter,Jeanne F. Nichols,Cheryl L. Rock,Veronica Irvin,Melanie S. Parker,Santiago A. Surillo,David Noel
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50 The South African Rea Phela Health Study: A randomized controlled trial of communication retention strategies
James M. Rhyne,Alexandra Mumbauer,Paul Rheeder,Megan N. Hall,Jeanine Genkinger,Andrew Medina-Marino,Charbel El Bcheraoui
PLOS ONE. 2018; 13(5): e0196900
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51 Effects of laying on of hands with and without a spiritual context on pain and functionality of older women with knee osteoarthritis: study protocol for a randomized controlled trial
Katy Andrade Monteiro Zacaron,Nélia da Silva Mendes,Yuri Cotta e Silva,Giancarlo Lucchetti
Journal of Integrative Medicine. 2018;
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52 A randomised controlled trial and economic evaluation of intraoperative cell salvage during caesarean section in women at risk of haemorrhage: the SALVO (cell SALVage in Obstetrics) trial
Khalid S Khan,Philip Moore,Matthew Wilson,Richard Hooper,Shubha Allard,Ian Wrench,Tracy Roberts,Carol McLoughlin,Lee Beresford,James Geoghegan,Jane Daniels,Sue Catling,Vicki A Clark,Paul Ayuk,Stephen Robson,Fang Gao-Smith,Matthew Hogg,Louise Jackson,Doris Lanz,Julie Dodds
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53 The effects of specialized treatment on the recidivism of juvenile sex offenders: a systematic review and meta-analysis
Heather Hensman Kettrey,Mark W. Lipsey
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54 Estimation of causal effects in clinical endpoint bioequivalence studies in the presence of intercurrent events: noncompliance and missing data
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55 Effectiveness of an app-based intervention for unintentional injury among caregivers of preschoolers: protocol for a cluster randomized controlled trial
Peishan Ning,Bo Chen,Peixia Cheng,Yang Yang,David C. Schwebel,Renhe Yu,Jing Deng,Shukun Li,Guoqing Hu
BMC Public Health. 2018; 18(1)
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56 “Being a bully isn’t very cool…”: Rap & Sing Music Therapy for enhanced emotional self-regulation in an adolescent school setting – a randomized controlled trial
Sylka Uhlig,Erik Jansen,Erik Scherder
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57 Meta-analysis comparing upfront surgery with neoadjuvant treatment in patients with resectable or borderline resectable pancreatic cancer
E. Versteijne,J. A. Vogel,M. G. Besselink,O. R. C. Busch,J. W. Wilmink,J. G. Daams,C. H. J. van Eijck,B. Groot Koerkamp,C. R. N. Rasch,G. van Tienhoven
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58 Electronic health record tools to assist with children’s insurance coverage: a mixed methods study
Jennifer E. DeVoe,Megan Hoopes,Christine A. Nelson,Deborah J. Cohen,Aleksandra Sumic,Jennifer Hall,Heather Angier,Miguel Marino,Jean P. O’Malley,Rachel Gold
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59 Statistical Basic Steps to Be Considered on Planning a Research
Cristina Pires Camargo,Rolf Gemperli
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60 Periodontal regenerative therapy for preventing bone defects distal to mandibular second molars after surgical removal of impacted third molars. A systematic review and meta-analysis of randomized clinical trials
Octavi Camps-Font,Cristina Caro-Bonfill,Maria Àngels Sánchez-Garcés,Cosme Gay-Escoda
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61 Neural connectivity during affect labeling predicts treatment response to psychological therapies for social anxiety disorder
Katherine S. Young,Richard T. LeBeau,Andrea N. Niles,Kean J. Hsu,Lisa J. Burklund,Bita Mesri,Darby Saxbe,Matthew D. Lieberman,Michelle G. Craske
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62 Dairy matrix effects: response to consumption of dairy fat differs when eaten within the cheese matrix—a randomized controlled trial
Emma L Feeney,Rebecca Barron,Victoria Dible,Zita Hamilton,Yvonne Power,Linda Tanner,Cal Flynn,Paul Bouchier,Tom Beresford,Nessa Noronha,Eileen R Gibney
The American Journal of Clinical Nutrition. 2018;
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63 Treatment of Neuroblastoma with a Novel Delayed Intensification Chemotherapy
Yu-tong Zhang,Jian Chang,Hong-mei Xu,Ya-nan Li,Xiao-dan Zhong,Zi-ling Liu
The Indian Journal of Pediatrics. 2018;
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64 Attention Deficit-Hyperactivity Disorder Group Visits Improve Parental Emotional Health and Perceptions of Child Behavior
Nerissa S. Bauer,Paula D. Sullivan,Dorota Szczepaniak,Sarah M. Stelzner,Amy Pottenger,Susan Ofner,Stephen M. Downs,Aaron E. Carroll
Journal of Developmental & Behavioral Pediatrics. 2018; : 1
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65 Exploratory study examining the at-home feasibility of a wearable tool for social-affective learning in children with autism
Jena Daniels,Jessey N. Schwartz,Catalin Voss,Nick Haber,Azar Fazel,Aaron Kline,Peter Washington,Carl Feinstein,Terry Winograd,Dennis P. Wall
npj Digital Medicine. 2018; 1(1)
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66 Does use of the LUCAS device improve mortality in adult patients with out-of-hospital cardiac arrest?
Rob Fenwick
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67 Plate fixation compared with nonoperative treatment of displaced midshaft clavicular fractures: a randomized clinical trial
A. H. Qvist,M. T. Væsel,C. M. Jensen,S. L. Jensen
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68 Arthroscopic Surgery or Physical Therapy for Patients With Femoroacetabular Impingement Syndrome: A Randomized Controlled Trial With 2-Year Follow-up
Nancy S. Mansell,Daniel I. Rhon,John Meyer,John M. Slevin,Bryant G. Marchant
The American Journal of Sports Medicine. 2018; 46(6): 1306
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69 A Plant-Based Dietary Intervention Improves Beta-Cell Function and Insulin Resistance in Overweight Adults: A 16-Week Randomized Clinical Trial
Hana Kahleova,Andrea Tura,Martin Hill,Richard Holubkov,Neal Barnard
Nutrients. 2018; 10(2): 189
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70 Reframing the approach to patients with hepatocellular carcinoma: Longitudinal assessment with hazard associated with liver transplantation for HCC (HALTHCC) improves ablate and wait strategy
Daniel J. Firl,Shoko Kimura,John McVey,Koji Hashimoto,Heidi Yeh,Charles M. Miller,James F. Markmann,Kazunari Sasaki,Federico N. Aucejo
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71 The Effectiveness of a Smartphone Application on Modifying the Intakes of Macro and Micronutrients in Primary Care: A Randomized Controlled Trial. The EVIDENT II Study
Jose Recio-Rodriguez,Cristina Agudo Conde,Maria Calvo-Aponte,Natividad Gonzalez-Viejo,Carmen Fernandez-Alonso,Nere Mendizabal-Gallastegui,Beatriz Rodriguez-Martin,Jose Maderuelo-Fernandez,Emiliano Rodriguez-Sanchez,Manuel Gomez-Marcos,Luis Garcia-Ortiz
Nutrients. 2018; 10(10): 1473
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72 Test-retest reliability of physiotherapists using the action research arm test in chronic stroke
Polykarpos Angelos Nomikos,Nicola Spence,Mansour Abdullah Alshehri
Journal of Physical Therapy Science. 2018; 30(10): 1271
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73 Effect of Huaier granule on recurrence after curative resection of HCC: a multicentre, randomised clinical trial
Qian Chen,Chang Shu,Arian D Laurence,Yan Chen,Bao-Gang Peng,Zuo-Jun Zhen,Jian-Qiang Cai,Yi-Tao Ding,Le-Qun Li,Yu-Bao Zhang,Qi-Chang Zheng,Ge-Liang Xu,Bo Li,Wei-Ping Zhou,Shou-Wang Cai,Xi-Yan Wang,Hao Wen,Xin-Yu Peng,Xue-Wen Zhang,Chao-Liu Dai,Ping Bie,Bao-Cai Xing,Zhi-Ren Fu,Lian-Xin Liu,Yi Mu,Ling Zhang,Qi-Shun Zhang,Bin Jiang,Hai-Xin Qian,Yi-Jun Wang,Jing-Feng Liu,Xi-Hu Qin,Qiang Li,Ping Yin,Zhi-Wei Zhang,Xiao-Ping Chen
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74 A constructive–critical response to The All-Party Arts, Health and Wellbeing Parliamentary Group report Creative Health: the Arts for Health and Wellbeing (July 2017)
Kate Phillips
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75 A novel complete-case analysis to determine statistical significance between treatments in an intention-to-treat population of randomized clinical trials involving missing data
Wei Liu,Jinhui Ding
Statistical Methods in Medical Research. 2018; 27(4): 1067
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76 Intensive home treatment for patients in acute psychiatric crisis situations: a multicentre randomized controlled trial
Jurgen Cornelis,Ansam Barakat,Jack Dekker,Tessy Schut,Sandra Berk,Hans Nusselder,Nikander Ruhl,Jeroen Zoeteman,Rien Van,Aartjan Beekman,Matthijs Blankers
BMC Psychiatry. 2018; 18(1)
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77 Trunk Exercises Improve Gait Symmetry in Parkinson Disease
Ryan P. Hubble,Geraldine Naughton,Peter A. Silburn,Michael H. Cole
American Journal of Physical Medicine & Rehabilitation. 2018; 97(3): 151
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78 Psychoeducational Intervention for Symptom Management of Fatigue, Pain and Sleep Disturbance Cluster among Cancer Patients: A Pilot Quasi-experimental Study
Ly Thuy Nguyen,Kimberly Alexander,Patsy Yates
Journal of Pain and Symptom Management. 2018;
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79 Technology Adoption by Older Adults: Findings From the PRISM Trial
Tracy L Mitzner,Jyoti Savla,Walter R Boot,Joseph Sharit,Neil Charness,Sara J Czaja,Wendy A Rogers
The Gerontologist. 2018;
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80 Association of Statin Use With Mortality After Dialysis-Requiring Acute Kidney Injury: A Population-Based Cohort Study
Chia-Lin Wu,Chew-Teng Kor,Chia-Chu Chang,Ping-Fang Chiu,Der-Cherng Tarng,Chih-Cheng Hsu
Mayo Clinic Proceedings. 2018; 93(10): 1474
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81 Resilience-Based Intervention With Underserved Children: Impact on Self-Regulation in a Randomized Clinical Trial in Schools
Brendan A. Rich,Nina D. Shiffrin,Colleen M. Cummings,Melissa M. Zarger,Lisa Berghorst,Mary K. Alvord
International Journal of Group Psychotherapy. 2018; : 1
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82 Study design and protocol for a culturally adapted cognitive behavioral stress and self-management intervention for localized prostate cancer: The Encuentros de Salud study
Frank J. Penedo,Michael H. Antoni,Patricia I. Moreno,Lara Traeger,Dolores Perdomo,Jason Dahn,Gregory E. Miller,Steve Cole,Julian Orjuela,Edgar Pizarro,Betina Yanez
Contemporary Clinical Trials. 2018; 71: 173
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83 Does Armodafinil Improve Driving Task Performance and Weight Loss in Sleep Apnea? A Randomized Trial
Julia L. Chapman,Elizabeth A. Cayanan,Camilla M. Hoyos,Yasmina Serinel,Maria Comas,Brendon J. Yee,Keith K. H. Wong,Ronald R. Grunstein,Nathaniel S. Marshall
American Journal of Respiratory and Critical Care Medicine. 2018; 198(7): 941
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84 Long-term effects of filmed social contact or internet-based self-study on mental health-related stigma: a 2-year follow-up of a randomised controlled trial
Sosei Yamaguchi,Yasutaka Ojio,Shuntaro Ando,Peter Bernick,Kazusa Ohta,Kei-ichiro Watanabe,Graham Thornicroft,Takuma Shiozawa,Shinsuke Koike
Social Psychiatry and Psychiatric Epidemiology. 2018;
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85 Gender-informed psycho-educational programme to promote respectful relationships and reduce postpartum common mental disorders among primiparous women: long-term follow-up of participants in a community-based cluster randomised controlled trial
Jane Fisher,Thach Tran,Karen Wynter,Harriet Hiscock,Jordana Bayer,Heather Rowe
Global Mental Health. 2018; 5
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86 Clinical evaluation of non-surgical cleaning modalities on titanium dental implants during maintenance care: a 1-year follow-up on prosthodontic superstructures
Kristina Emily Schmidt,Thorsten Mathias Auschill,Anton Sculean,Nicole Birgit Arweiler
Clinical Oral Investigations. 2018;
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87 Comparative effectiveness of individualised homeopathy and antibiotics in the treatment of bovine clinical mastitis: randomised controlled trial
Diana Keller,Albert Sundrum
Veterinary Record. 2018; 182(14): 407
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88 Social Robots for Depression in Older Adults: A Systematic Review
Shu-Chuan Chen,Cindy Jones,Wendy Moyle
Journal of Nursing Scholarship. 2018;
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89 An integrated approach to mental health and disaster preparedness: a cluster comparison with earthquake affected communities in Nepal
Courtney Welton-Mitchell,Leah Emily James,Shree Niwas Khanal,Alexander Scott James
BMC Psychiatry. 2018; 18(1)
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90 Online versus Offline Promotional Communication
Marco Ieva,Cristina Ziliani,Juan Carlos Gázquez-Abad,Ida DæAttoma
Journal of Advertising Research. 2018; 58(3): 338
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91 An after-school intervention targeting executive function and visuospatial skills also improves classroom behavior
Laura L. Brock,William M. Murrah,Elizabeth A. Cottone,Andrew J. Mashburn,David W. Grissmer
International Journal of Behavioral Development. 2018; 42(5): 474
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92 A Liftless Intervention to Prevent Preterm Birth and Low Birthweight Among Pregnant Ghanaian Women: Protocol of a Stepped-Wedge Cluster Randomized Controlled Trial
Emma Kwegyir-Afful,Jos Verbeek,Lydia Aziato,Joseph D Seffah,Kimmo Räsänen
JMIR Research Protocols. 2018; 7(8): e10095
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93 WELCOME: improving WEight controL and CO-Morbidities in children with obesity via Executive function training: study protocol for a randomized controlled trial
Tiffany Naets,Leentje Vervoort,Marijke Ysebaert,Annelies Van Eyck,Stijn Verhulst,Luc Bruyndonckx,Benedicte De Winter,Kim Van Hoorenbeeck,Ann Tanghe,Caroline Braet
BMC Public Health. 2018; 18(1)
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94 A confirmatory study on the efficacy of dehydrated human amnion/chorion membrane dHACM allograft in the management of diabetic foot ulcers: A prospective, multicentre, randomised, controlled study of 110 patients from 14 wound clinics
William Tettelbach,Shawn Cazzell,Alexander M Reyzelman,Felix Sigal,Joseph M Caporusso,Patrick S Agnew
International Wound Journal. 2018;
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95 Impact of Medicaid Managed Care on Illinoisæs Acute Health Services Expenditures for Adults With Intellectual and Developmental Disabilities
Kiyoshi Yamaki,Coady Wing,Dale Mitchell,Randall Owen,Tamar Heller
Intellectual and Developmental Disabilities. 2018; 56(2): 133
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96 Te Whanau Pou Toru: a Randomized Controlled Trial (RCT) of a Culturally Adapted Low-Intensity Variant of the Triple P-Positive Parenting Program for Indigenous Maori Families in New Zealand
Louise J. Keown,Matthew R. Sanders,Nike Franke,Matthew Shepherd
Prevention Science. 2018;
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97 Baclofen: its effectiveness in reducing harmful drinking, craving, and negative mood. A meta-analysis
Abigail K. Rose,Andrew Jones
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98 Investigating the Impact of Hearing Aid Use and Auditory Training on Cognition, Depressive Symptoms, and Social Interaction in Adults With Hearing Loss: Protocol for a Crossover Trial
Joanna Nkyekyer,Denny Meyer,Peter J Blamey,Andrew Pipingas,Sunil Bhar
JMIR Research Protocols. 2018; 7(3): e85
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99 The key role of positive parenting and children’s temperament in post-institutionalized children’s socio-emotional adjustment after adoption placement. A RCT study
Lavinia Barone,Yagmur Ozturk,Francesca Lionetti
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100 The Impact of Time of Mobilization After Split Thickness Skin Graft on Lower Extremity Wound Healing—Systematic Review and Meta-analysis
Helene Retrouvey,Annie Wang,Joseph Corkum,Shahriar Shahrokhi
Journal of Burn Care & Research. 2018;
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101 Pilot Randomized Trial of an Automated Smoking Cessation Intervention via Mobile Phone Text Messages as an Adjunct to Varenicline in Primary Care
Jessica M. Yingst,Susan Veldheer,Shari Hrabovsky,Erin Hammett,James Nicholson,Arthur Berg,Jonathan Foulds
Journal of Health Communication. 2018; : 1
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102 Window to Hope
Lisa A. Brenner,Jeri E. Forster,Adam S. Hoffberg,Bridget B. Matarazzo,Trisha A. Hostetter,Gina Signoracci,Grahame K. Simpson
Journal of Head Trauma Rehabilitation. 2017; : 1
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103 Patient Satisfaction on Overactive Bladder Treatment
Kimberly Tay,Aqsa Khan
Current Bladder Dysfunction Reports. 2017;
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104 Evaluation of the impact of disease prevention measures: a methodological note on defining incidence rates
Yin-Bun Cheung,Ying Xu,Matthew Cairns,Paul Milligan
BMC Medical Research Methodology. 2017; 17(1)
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105 Physical Activity on Prescription (PAP), in patients with metabolic risk factors. A 6-month follow-up study in primary health care
Stefan Lundqvist,Mats Börjesson,Maria E. H. Larsson,Lars Hagberg,Åsa Cider,Yvonne Böttcher
PLOS ONE. 2017; 12(4): e0175190
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106 Clinical and cost effectiveness of nurse-led self-management interventions for patients with copd in primary care: A systematic review
Elizabeth Baker,Francis Fatoye
International Journal of Nursing Studies. 2017; 71: 125
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107 Ischemic compression and kinesiotherapy on chronic myofascial pain in breast cancer survivors
Flávia Belavenuto Rangon,Vânia Tiê Koga Ferreira,Monique Silva Rezende,Amanda Apolinário,Ana Paula Ferro,Elaine Caldeira de Oliveira Guirro
Journal of Bodywork and Movement Therapies. 2017;
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108 A randomized clinical trial of oral hygiene care programmes during stroke rehabilitation
Ruoxi Dai,Otto L.T. Lam,Edward C.M. Lo,Leonard S.W. Li,Colman McGrath
Journal of Dentistry. 2017;
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109 Long-term abstinence and predictors of tobacco treatment uptake among hospitalized smokers with serious mental illness enrolled in a smoking cessation trial
Erin S. Rogers,Rebecca Friedes,Annika Jakes,Ellie Grossman,Alissa Link,Scott E. Sherman
Journal of Behavioral Medicine. 2017;
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110 Understanding the Mechanisms of Change in a Lifestyle Intervention for Older Adults
Christine Juang,Bob G. Knight,Mike Carlson,Stacey L. Schepens Niemiec,Cheryl Vigen,Florence Clark
The Gerontologist. 2017;
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111 Increasing Physical Activity Through Principles of Habit Formation in New Gym Members: a Randomized Controlled Trial
Navin Kaushal,Ryan E. Rhodes,John C. Spence,John T. Meldrum
Annals of Behavioral Medicine. 2017;
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112 Feeling Thanks and Saying Thanks: A Randomized Controlled Trial Examining If and How Socially Oriented Gratitude Journals Work
Brenda H. OæConnell,Deirdre OæShea,Stephen Gallagher
Journal of Clinical Psychology. 2017;
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113 No additional benefit of using a calcium hydroxide liner during stepwise caries removal
Maria Auxiliadora Pereira,Reginaldo Batista dos Santos-Júnior,Johnny Alexandre Tavares,Alaíde Hermínia Oliveira,Pollyana Caldeira Leal,Wilton Mitsunari Takeshita,Antônio Márcio Barbosa-Júnior,Luiz Eduardo Braga Bertassoni,André Luis Faria-e-Silva
The Journal of the American Dental Association. 2017;
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114 Effectiveness of pulmonary rehabilitation for patients with asthma: study protocol of a randomized controlled trial (EPRA)
Konrad Schultz,Hildegard Seidl,Danijel Jelusic,Rupert Wagner,Michael Wittmann,Hermann Faller,Dennis Nowak,Michael Schuler
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115 Challenges in implementing an exercise intervention within residential psychiatric care: A mixed methods study
Joseph Firth,Rebekah Carney,Michelle Pownall,Paul French,Rebecca Elliott,Jack Cotter,Alison R. Yung
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116 Incomplete descriptions of oral nutritional supplement interventions in reports of randomised controlled trials
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117 Testing the limits: Extending attachment-based intervention effects to infant cognitive outcome and parental stress
Karine Dubois-Comtois,Chantal Cyr,George M. Tarabulsy,Diane St-Laurent,Annie Bernier,Ellen Moss
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118 Online Self-Tracking Groups to Increase Fruit and Vegetable Intake: A Small-Scale Study on Mechanisms of Group Effect on Behavior Change
Jingbo Meng,Wei Peng,Soo Yun Shin,Minwoong Chung
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119 Outcomes of a family-based HIV prevention intervention for substance using juvenile offenders
Marina Tolou-Shams,Emily Dauria,Selby M. Conrad,Kathleen Kemp,Sarah Johnson,Larry K. Brown
Journal of Substance Abuse Treatment. 2017; 77: 115
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120 Formal Physical Therapy After Total Hip Arthroplasty Is Not Required
Matthew S. Austin,Brian T. Urbani,Andrew N. Fleischman,Navin D. Fernando,James J. Purtill,William J. Hozack,Javad Parvizi,Richard H. Rothman
The Journal of Bone and Joint Surgery. 2017; 99(8): 648
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121 The effectiveness of braces and orthoses for patients with knee osteoarthritis: A systematic review of Japanese-language randomised controlled trials
Koya Mine,Takashi Nakayama,Steve Milanese,Karen Grimmer
Prosthetics and Orthotics International. 2017; 41(2): 115
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122 Resistance training prescription with different load-management methods improves phase angle in older women
Alex S. Ribeiro,Brad J. Schoenfeld,Mariana F. Souza,Crisieli M. Tomeleri,Analiza M. Silva,Denílson C. Teixeira,Luís B. Sardinha,Edilson S. Cyrino
European Journal of Sport Science. 2017; : 1
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123 Angiotensin II/Angiotensin (1–7) ratio and 24-h blood pressure throughout the menstrual cycle and in women using oral contraceptives
Gina C. Davis,Karen J. Gibson,David Casley,Mark A. Brown
Journal of Hypertension. 2017; 35(6): 1178
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124 The Effects of Home-Based Cognitive Training on Verbal Working Memory and Language Comprehension in Older Adulthood
Brennan R. Payne,Elizabeth A. L. Stine-Morrow
Frontiers in Aging Neuroscience. 2017; 9
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125 Direct provision versus facility collection of HIV self-tests among female sex workers in Uganda: A cluster-randomized controlled health systems trial
Katrina Ortblad,Daniel Kibuuka Musoke,Thomson Ngabirano,Aidah Nakitende,Jonathan Magoola,Prossy Kayiira,Geoffrey Taasi,Leah G. Barresi,Jessica E. Haberer,Margaret A. McConnell,Catherine E. Oldenburg,Till Bärnighausen,Elvin H. Geng
PLOS Medicine. 2017; 14(11): e1002458
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126 A Twelve-Week Moderate Exercise Programme Improved Symptoms of Depression, Insomnia, and Verbal Learning in Post-Aneurysmal Subarachnoid Haemorrhage Patients: A Comparison with Meningioma Patients and Healthy Controls
Flora Colledge,Serge Brand,Uwe Pühse,Edith Holsboer-Trachsler,Stefan Zimmerer,Ramona Schleith,Markus Gerber
Neuropsychobiology. 2017; 76(2): 59
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127 Effectiveness of job rotation for preventing work-related musculoskeletal diseases: a cluster randomised controlled trial
Maria Luiza Caires Comper,Jack Tigh Dennerlein,Gabriela dos Santos Evangelista,Patricia Rodrigues da Silva,Rosimeire Simprini Padula
Occupational and Environmental Medicine. 2017; 74(8): 543.1
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128 The influence of 3 months of physical exercises and verbal stimulation on functional efficiency and use of free time in an older population under institutional care: study protocol for a randomized controlled trial
Agnieszka Wisniowska-Szurlej,Agnieszka Cwirlej-Sozanska,Anna Wilmowska-Pietruszynska,Natalia Milewska,Bernard Sozanski
Trials. 2017; 18(1)
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129 A tailored video intervention to reduce smoking and environmental tobacco exposure during and after pregnancy: Rationale, design and methods of Babyæs Breath
Patricia Markham Risica,Adam Gavarkovs,Donna R. Parker,Ernestine Jennings,Maureen Phipps
Contemporary Clinical Trials. 2017; 52: 1
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130 Clinical trial methodology to assess the efficacy/effectiveness of long-acting antipsychotics: Randomized controlled trials vs naturalistic studies
Andrea Fagiolini,Paola Rocca,Serafino De Giorgi,Edoardo Spina,Giovanni Amodeo,Mario Amore
Psychiatry Research. 2017; 247: 257
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131 Allopurinol as add-on treatment for mania symptoms in bipolar disorder: systematic review and meta-analysis of randomised controlled trials
Francesco Bartoli,Cristina Crocamo,Massimo Clerici,Giuseppe Carrà
The British Journal of Psychiatry. 2017; 210(1): 10
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132 A randomized clinical trial comparing long-term clopidogrel vs aspirin monotherapy beyond dual antiplatelet therapy after drug-eluting coronary stent implantation: Design and rationale of the Harmonizing Optimal Strategy for Treatment of coronary artery stenosis-Extended Antiplatelet Monotherapy (HOST-EXAM) trial
Heesun Lee,Bon-Kwon Koo,Kyung Woo Park,Eun-Seok Shin,Sang Wook Lim,Seung-Woon Rha,Jang-Whan Bae,Dong Woon Jeon,Seok-Kyu Oh,Seung-Ho Hur,Bum-Su Kim,Jung-Hee Lee,Tae-Ho Park,Nam Ho Lee,Hyo-Soo Kim
American Heart Journal. 2017; 185: 17
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133 Feasibility and Acceptability of a Task-Shifted Intervention to Enhance Adherence to HIV Medication and Improve Depression in People Living with HIV in Zimbabwe, a Low Income Country in Sub-Saharan Africa
Melanie Abas,Primrose Nyamayaro,Tarisai Bere,Emily Saruchera,Nomvuyo Mothobi,Victoria Simms,Walter Mangezi,Kirsty Macpherson,Natasha Croome,Jessica Magidson,Azure Makadzange,Steven Safren,Dixon Chibanda,Conall O’Cleirigh
AIDS and Behavior. 2017;
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134 An Experimental Evaluation of the Impact of Intensive Supervision on the Recidivism of High-Risk Probationers
Jordan M. Hyatt,Geoffrey C. Barnes
Crime & Delinquency. 2017; 63(1): 3
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135 Impact of industry collaboration on randomised controlled trials in oncology
Anne Linker,Annie Yang,Nitin Roper,Evans Whitaker,Deborah Korenstein
European Journal of Cancer. 2017; 72: 71
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136 Quality of reporting for randomized controlled trials in the hypospadias literature: where do we stand?
L.H. Braga,M. McGrath,L. Mauro,A.J. Lorenzo
Journal of Pediatric Urology. 2017;
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137 Early introduction of food reduces food allergy - Pro and Con
Debra J. Palmer,Susan L. Prescott,Michael R. Perkin
Pediatric Allergy and Immunology. 2017; 28(3): 214
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138 Increasing boys’ and girls’ intentions to avoid teenage pregnancy: a cluster randomised controlled feasibility trial of an interactive video drama-based intervention in post-primary schools in Northern Ireland
Maria Lohan,Áine Aventin,Lisa Maguire,Rhonda Curran,Clíona McDowell,Ashley Agus,Cam Donaldson,Mike Clarke,Mark Linden,Carmel Kelly,Lisa McDaid,Laura Dunne,Peter O’Halloran
Public Health Research. 2017; 5(1): 1
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139 Effects of the ABC Intervention on Foster Children’s Receptive Vocabulary: Follow-Up Results From a Randomized Clinical Trial
Kristin Bernard,Amy Hyoeun Lee,Mary Dozier
Child Maltreatment. 2017; 22(2): 174
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140 Outcomes of a Randomized Controlled Trial of Genomic Counseling for Patients Receiving Personalized and Actionable Complex Disease Reports
Kevin Sweet,Amy C. Sturm,Tara Schmidlen,Joseph McElroy,Laura Scheinfeldt,Kandamurugu Manickam,Erynn S. Gordon,Shelly Hovick,J. Scott Roberts,Amanda Ewart Toland,Michael Christman
Journal of Genetic Counseling. 2017;
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141 The impact of supplementation with dietary fibers on weight loss: A systematic review of randomised controlled trials
Kia Yong Chew,Iain A. Brownlee
Bioactive Carbohydrates and Dietary Fibre. 2017;
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142 Moving From Efficacy to Effectiveness
Jessica Saunders,Michael Robbins,Allison J. Ober
Criminology & Public Policy. 2017;
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143 Brief Report on the Psychophysiological Effects of a Yoga Intervention for Chronic Stress
Kaitlin N. Harkess,Paul Delfabbro,Jane Mortimer,Zara Hannaford,Sarah Cohen-Woods
Journal of Psychophysiology. 2017; 31(1): 38
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144 Do People With Severe Traumatic Brain Injury Benefit From Making Errors? A Randomized Controlled Trial of Error-Based and Errorless Learning
Tamara Ownsworth,Jennifer Fleming,Robyn Tate,Elizabeth Beadle,Janelle Griffin,Melissa Kendall,Julia Schmidt,Amanda Lane-Brown,Mathilde Chevignard,David H. K. Shum
Neurorehabilitation and Neural Repair. 2017; 31(12): 1072
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145 The use of an antioxidant dressing on hard-to-heal wounds: a multicentre, prospective case series
B. Castro,F.D. Bastida,T. Segovia,P. López Casanova,J.J. Soldevilla,J. Verdú-Soriano
Journal of Wound Care. 2017; 26(12): 742
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146 Non-inferiority trials: No better? No worse? No change? No pain?
Robert K. Hills
British Journal of Haematology. 2017;
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147 Mindfulness-Based Relapse Prevention for Methadone Maintenance: A Feasibility Trial
Sarah Bowen,Vanessa C. Somohano,Rachel E. Rutkie,Jacob A. Manuel,Kristoffer L. Rehder
The Journal of Alternative and Complementary Medicine. 2017;
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148 Enhanced self-efficacy after a self-management programme in pituitary disease: a randomized controlled trial
Cornelie D Andela,Han Repping-Wuts,Nike M M L Stikkelbroeck,Mathilde C Pronk,Jitske Tiemensma,Ad R Hermus,Adrian A Kaptein,Alberto M Pereira,Noelle G A Kamminga,Nienke R Biermasz
European Journal of Endocrinology. 2017; 177(1): 59
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149 Elemental diet decreases inflammation and improves symptoms in adult eosinophilic oesophagitis patients
M. J. Warners,B. J. Vlieg-Boerstra,J. Verheij,B. D. van Rhijn,M. T. J. Van Ampting,L. F. Harthoorn,W. J. de Jonge,A. J. P. M. Smout,A. J. Bredenoord
Alimentary Pharmacology & Therapeutics. 2017;
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150 Home-Based Parent Child Therapy for Young Traumatized Children Living In Poverty: A Randomized Controlled Trial
Joanna R. Love,Robert A. Fox
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151 A Follow-Up Study from a Multisite, Randomized Controlled Trial for Traumatized Children Receiving TF-CBT
Tine K. Jensen,Tonje Holt,Silje M. Ormhaug
Journal of Abnormal Child Psychology. 2017;
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152 La recherche d’effectivité: nature, méthodes et rôle dans la validation des interventions fondées sur les preuves
Frédéric Nault Brière
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153 Cluster randomised controlled trial of a consumer behaviour intervention to improve healthy food purchases from online canteens: study protocol
Tessa Delaney,Rebecca Wyse,Sze Lin Yoong,Rachel Sutherland,John Wiggers,Kylie Ball,Karen Campbell,Chris Rissel,Luke Wolfenden
BMJ Open. 2017; 7(4): e014569
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154 Effectiveness of a motionless ultrasonic toothbrush in reducing plaque and gingival inflammation in patients with fixed orthodontic appliances
Thayika Saruttichart,Pintu-on Chantarawaratit,Chalermpol Leevailoj,Panida Thanyasrisung,Waranuch Pitiphat,Oranart Matangkasombut
The Angle Orthodontist. 2017; 87(2): 279
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155 Web- and text-based interventions for smoking cessation: Meta-analysis and meta-regression
Cristina Crocamo,Daniele Carretta,Marica Ferri,Sonia Dias,Francesco Bartoli,Giuseppe Carrá
Drugs: Education, Prevention and Policy. 2017; : 1
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156 Effects of mind-body interventions on depressive symptoms among older Chinese adults: a systematic review and meta-analysis
Ai Bo,Weiyu Mao,Michael A. Lindsey
International Journal of Geriatric Psychiatry. 2017;
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157 Complex self-management interventions in chronic disease unravelled: a review of lessons learned from an individual patient data meta-analysis
Nini H. Jonkman,Rolf H.H. Groenwold,Jaap C.A. Trappenburg,Arno W. Hoes,Marieke J. Schuurmans
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158 Attrition in trials evaluating complex interventions for schizophrenia: Systematic review and meta-analysis
P. Szymczynska,S. Walsh,L. Greenberg,S. Priebe
Journal of Psychiatric Research. 2017; 90: 67
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159 The feeling of discomfort during vaginal examination, history of abuse and sexual abuse and post-traumatic stress disorder in women
Gizem Günes,Zekiye Karaçam
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160 Health promotion and preventive care intervention for older community-dwelling people: Long-term effects of a randomised controlled trial (RCT) within the LUCAS cohort
Lilli Neumann,U. Dapp,W. von Renteln-Kruse,C. E. Minder
The journal of nutrition, health & aging. 2017;
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161 Strategic Resource Use for Learning: A Self-Administered Intervention That Guides Self-Reflection on Effective Resource Use Enhances Academic Performance
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Psychological Science. 2017; 28(6): 774
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162 Impact of Narrative Expressive Writing on Heart Rate, Heart Rate Variability, and Blood Pressure After Marital Separation
Kyle J. Bourassa,John J.B. Allen,Matthias R. Mehl,David A. Sbarra
Psychosomatic Medicine. 2017; 79(6): 697
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163 Ten Important Considerations for Ovarian Cancer Screening
Edward Pavlik
Diagnostics. 2017; 7(2): 22
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164 Effectiveness of family group conferencing in preventing repeat referrals to child protective services and out-of-home placements
Dana M. Hollinshead,Tyler W. Corwin,Erin J. Maher,Lisa Merkel-Holguin,Heather Allan,John D. Fluke
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165 The effect of tinnitus retraining therapy on chronic tinnitus: A controlled trial
Carol A. Bauer,Jennifer L. Berry,Thomas J. Brozoski
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166 Electronic-based lifestyle interventions in overweight or obese perinatal women: a systematic review and meta-analysis
Y. Lau,P. Klainin-Yobas,T. P. Htun,S. N. Wong,K. L. Tan,S. T. Ho-Lim,C. Chi,C. Tsai,K. W. Ong,S. Shorey,W. S. W. Tam
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167 A randomized clinical trial of a human acellular dermal matrix demonstrated superior healing rates for chronic diabetic foot ulcers over conventional care and an active acellular dermal matrix comparator
Shawn Cazzell,Dean Vayser,Hau Pham,Jodi Walters,Alexander Reyzelman,Brian Samsell,Kimberly Dorsch,Mark Moore
Wound Repair and Regeneration. 2017;
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168 A multimodal day treatment program for multi-problem young adults: study protocol for a randomized controlled trial
Marie-Jolette A. Luijks,Floor Bevaart,Josjan Zijlmans,Laura van Duin,Reshmi Marhe,Theo A. H. Doreleijers,Henning Tiemeier,Jessica J. Asscher,Arne Popma
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169 The XprESS Multi-Sinus Dilation System for the Treatment of Chronic Sinusitis: A NICE Medical Technology Guidance
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Applied Health Economics and Health Policy. 2017;
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170 Dancing for Parkinson Disease: A Randomized Trial of Irish Set Dancing Compared With Usual Care
Joanne Shanahan,Meg E. Morris,Orfhlaith Ni Bhriain,Daniele Volpe,Tim Lynch,Amanda M. Clifford
Archives of Physical Medicine and Rehabilitation. 2017;
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171 Second-Order Peer Reviews of Clinically Relevant Articles for the Physiatrist
Byron J. Schneider,David J. Kennedy,Dinesh Kumbhare
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172 Impact of Adding a Decision Aid to Patient Education in Adults with Asthma: A Randomized Clinical Trial
Myriam E. Gagné,France Légaré,Jocelyne Moisan,Louis-Philippe Boulet,Christophe Leroyer
PLOS ONE. 2017; 12(1): e0170055
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173 Per-Protocol Analyses of Pragmatic Trials
Miguel A. Hernán,James M. Robins
New England Journal of Medicine. 2017; 377(14): 1391
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174 Comparison between intra-articular ozone and placebo in the treatment of knee osteoarthritis: A randomized, double-blinded, placebo-controlled study
Carlos César Lopes de Jesus,Fânia Cristina dos Santos,Luciana Maria Oliveira Bueno de Jesus,Iara Monteiro,Maria Sonia Sousa Castro Sant’Ana,Virginia Fernandes Moça Trevisani,Jan P. A. Baak
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175 Focused breastfeeding counselling improves short- and long-term success in an early-discharge setting: A cluster-randomized study
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Maternal & Child Nutrition. 2017; 13(4): e12432
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176 Accounting for Uncertainty in Decision Analytic Models Using Rank Preserving Structural Failure Time Modeling: Application to Parametric Survival Models
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Value in Health. 2017;
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177 "The Role of Phacoemulsification in Glaucoma Therapy: A Systematic Review and Meta-analysis”
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178 Fecal transplantation for treatment of inflammatory bowel disease
Aamer Imdad,Maribeth R Nicholson,Emily E Tanner-Smith,Joseph P Zackular,Oscar Gomez-Duarte,Dawn M Borromeo Beaulieu,Sari Acra
Cochrane Database of Systematic Reviews. 2017;
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179 Effectiveness of a universal classroom-based preventive intervention (PAX GBG): A research protocol for a matched-pair cluster-randomized controlled trial
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Contemporary Clinical Trials Communications. 2017; 8: 75
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180 Jigsaw Puzzles As Cognitive Enrichment (PACE) - the effect of solving jigsaw puzzles on global visuospatial cognition in adults 50 years of age and older: study protocol for a randomized controlled trial
Patrick Fissler,Olivia C. Küster,Laura S. Loy,Daria Laptinskaya,Martin J. Rosenfelder,Christine A. F. von Arnim,Iris-Tatjana Kolassa
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181 Ineffectiveness of commercial weight-loss programs for achieving modest but meaningful weight loss: Systematic review and meta-analysis
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Journal of Health Psychology. 2017; 22(12): 1614
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182 Psycho-educational intervention on mood in patients suffering from colorectal and anal cancer: A randomized controlled trial
Emma Ohlsson-Nevo,Birgitta Andershed,Ulrica Nilsson
Nordic Journal of Nursing Research. 2017; 37(3): 135
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183 Long-term endurance training improves general health perception in multiple sclerosis patients with fatigue: results of an exploratory study
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Sport Sciences for Health. 2017;
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184 Designing clinical studies in orthopedic traumatology
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Orthopaedics & Traumatology: Surgery & Research. 2017;
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185 Feasibility and efficacy of an attachment-based intervention in a maltreatment sample in residential care: A pilot study
Marta Casonato,Sarah Nazzari,Alessandra Frigerio
Clinical Child Psychology and Psychiatry. 2017; 22(4): 561
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186 Health-related quality of life among older patients following an emergency department visit and emergency department-to-home coaching intervention: A randomized controlled trial
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187 The Use of Acceptance and Commitment Therapy to Promote Mental Health and School Engagement in University Students: A Multisite Randomized Controlled Trial
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Behavior Therapy. 2017;
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188 Intermittent energy restriction improves weight loss efficiency in obese men: the MATADOR study
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189 Efficacy of an adaptation of the Best Possible Self intervention implemented through positive technology: a randomized control trial
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190 The use of case management for community-dwelling older people: the effects on loneliness, symptoms of depression and life satisfaction in a randomised controlled trial
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191 Wound healing outcomes: Using big data and a modified intent-to-treat method as a metric for reporting healing rates
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192 Performance of automated activity monitoring systems used in combination with timed artificial insemination compared to timed artificial insemination only in early lactation in dairy cows
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193 Lessons Learned from Large-Scale Randomized Experiments
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194 “Active Team” a social and gamified app-based physical activity intervention: randomised controlled trial study protocol
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195 The Impact of Family-Centered Prevention on Self-Regulation and Subsequent Long-Term Risk in Emerging Adults
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196 Improving school performance among Swedish foster children: A quasi-experimental study exploring outcomes of the Skolfam model
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197 A non-randomised pragmatic trial of a school-based group cognitive-behavioural programme for preventing depression in girls
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198 Systematic review of the association between physical activity and burnout
Lea M. Naczenski,Juriena D. de Vries,Madelon L. M. van Hooff,Michiel A. J. Kompier
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199 Using Lean Quality Improvement Tools to Increase Delivery of Evidence-Based Tobacco Use Treatment in Hospitalized Neurosurgical Patients
Laurel Sisler,Oluwaseun Omofoye,Karina Paci,Eldad Hadar,Adam O. Goldstein,Carol Ripley-Moffitt
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200 Change and dispersion of QT interval during treatment with quetiapine extended release versus aripiprazole in children and adolescents with first-episode psychosis: results from the TEA trial
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201 Intention-to-treat and transparency of related practices in randomized, controlled trials of anti-infectives
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202 The Primary Outcome Fails — What Next?
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New England Journal of Medicine. 2016; 375(9): 861
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203 TREATMENT SWITCHING: STATISTICAL AND DECISION-MAKING CHALLENGES AND APPROACHES
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204 Belotecan/cisplatin versus etoposide/cisplatin in previously untreated patients with extensive-stage small cell lung carcinoma: a multi-center randomized phase III trial
In-Jae Oh,Kyu-Sik Kim,Cheol-Kyu Park,Young-Chul Kim,Kwan-Ho Lee,Jin-Hong Jeong,Sun-Young Kim,Jeong-Eun Lee,Kye-Chul Shin,Tae-Won Jang,Hyun-Kyung Lee,Kye-Young Lee,Sung-Yong Lee
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205 INDIVIDUO: Results from a patient-centered lifestyle intervention for obesity surgery candidates
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206 Effect of choir activity in the rehabilitation of aphasia: a blind, randomised, controlled pilot study
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207 Resistance training improves inflammatory level, lipid and glycemic profiles in obese older women: A randomized controlled trial
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208 Cross-centre replication of suppressed burrowing behaviour as an ethologically relevant pain outcome measure in the rat
Rachel Wodarski,Ada Delaney,Camilla Ultenius,Rosie Morland,Nick Andrews,Catherine Baastrup,Luke A. Bryden,Ombretta Caspani,Thomas Christoph,Natalie J. Gardiner,Wenlong Huang,Jeffrey D. Kennedy,Suguru Koyama,Dominic Li,Marcin Ligocki,Annika Lindsten,Ian Machin,Anton Pekcec,Angela Robens,Sanziana M. Rotariu,Sabrina Vo,Marta Segerdahl,Carina Stenfors,Camilla I. Svensson,Rolf-Detlef Treede,Katsuhiro Uto,Kazumi Yamamoto,Kris Rutten,Andrew S.C. Rice
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209 Effect of a Digital Social Media Campaign on Young Adult Smoking Cessation
Neill Bruce Baskerville,Sunday Azagba,Cameron Norman,Kyle McKeown,K. Stephen Brown
Nicotine & Tobacco Research. 2016; 18(3): 351
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210 Randomized evaluation and cost-effectiveness of HIV and sexual and reproductive health service referral and linkage models in Zambia
Paul C. Hewett,Mutinta Nalubamba,Fiammetta Bozzani,Jean Digitale,Lung Vu,Eileen Yam,Mary Nambao
BMC Public Health. 2016; 16(1)
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211 Efficacy of Internet-Based Self-Monitoring Interventions on Maternal and Neonatal Outcomes in Perinatal Diabetic Women: A Systematic Review and Meta-Analysis
Ying Lau,Tha Pyai Htun,Suei Nee Wong,Wai San Wilson Tam,Piyanee Klainin-Yobas
Journal of Medical Internet Research. 2016; 18(8): e220
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212 Continuity of care by a primary midwife (caseload midwifery) increases women’s satisfaction with antenatal, intrapartum and postpartum care: results from the COSMOS randomised controlled trial
Della A. Forster,Helen L. McLachlan,Mary-Ann Davey,Mary Anne Biro,Tanya Farrell,Lisa Gold,Maggie Flood,Touran Shafiei,Ulla Waldenström
BMC Pregnancy and Childbirth. 2016; 16(1)
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213 A Randomized Controlled Trial of the Effectiveness of Traditional and Mobile Public Health Communications With Health Care Providers
Janet Baseman,Debra Revere,Ian Painter,Mark Oberle,Jeffrey Duchin,Hanne Thiede,Randall Nett,Dorothy MacEachern,Andy Stergachis
Disaster Medicine and Public Health Preparedness. 2016; 10(01): 98
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214 PTSD REMISSION AFTER PROLONGED EXPOSURE TREATMENT IS ASSOCIATED WITH ANTERIOR CINGULATE CORTEX THINNING AND VOLUME REDUCTION
Liat Helpman,Santiago Papini,Binod T. Chhetry,Erel Shvil,Mikael Rubin,Gregory M. Sullivan,John C. Markowitz,J. John Mann,Yuval Neria
Depression and Anxiety. 2016; : n/a
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215 The effect of primary midwife-led care on womenæs experience of childbirth: results from the COSMOS randomised controlled trial
HL McLachlan,DA Forster,M-A Davey,T Farrell,M Flood,T Shafiei,U Waldenström
BJOG: An International Journal of Obstetrics & Gynaecology. 2016; 123(3): 465
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216 Effect of Sirolimus on Disease Progression in Patients with Autosomal Dominant Polycystic Kidney Disease and CKD Stages 3b-4
P. Ruggenenti,G. Gentile,N. Perico,A. Perna,L. Barcella,M. Trillini,M. Cortinovis,C. P. Ferrer Siles,J. A. Reyes Loaeza,M. C. Aparicio,G. Fasolini,F. Gaspari,D. Martinetti,F. Carrara,N. Rubis,S. Prandini,A. Caroli,K. Sharma,L. Antiga,A. Remuzzi,G. Remuzzi
Clinical Journal of the American Society of Nephrology. 2016;
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217 Long-term efficacy and safety of etravirine-containing regimens in a real-life cohort of treatment-experienced HIV-1-infected patients
Clotilde Allavena,Christine Katlama,Laurent Cotte,Pierre Marie Roger,Pierre Delobel,Antoine Cheret,Claudine Duvivier,Isabelle Poizot-Martin,Bruno Hoen,André Cabie,Arnaud Cheret,Rima Lahoulou,François Raffi,Pascal Pugliese
Infectious Diseases. 2016; 48(5): 392
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218 „Intention to treat“ oder „treatment as received“ – Umgang mit Abbrechern in der Forschung zur Straftäterbehandlung
Johann Endres,Maike M. Breuer,Mark Stemmler
Forensische Psychiatrie, Psychologie, Kriminologie. 2016; 10(1): 45
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219 Two-Year COMPASS Trial Results: Supraciliary Microstenting with Phacoemulsification in Patients with Open-Angle Glaucoma and Cataracts
Steven Vold,Iqbal Ike K. Ahmed,E. Randy Craven,Cynthia Mattox,Robert Stamper,Mark Packer,Reay H. Brown,Tsontcho Ianchulev
Ophthalmology. 2016;
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220 Art therapy for people with psychosis: a narrative review of the literature
Angelica Attard,Michael Larkin
The Lancet Psychiatry. 2016;
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221 Can predilatation in transcatheter aortic valve implantation be omitted? - a prospective randomized study
Henrik Casimir Ahn,Niels-Erik Nielsen,Jacek Baranowski
Journal of Cardiothoracic Surgery. 2016; 11(1)
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222 Home-Based Psychiatric Outpatient Care Through Videoconferencing for Depression: A Randomized Controlled Follow-Up Trial
Ines Hungerbuehler,Leandro Valiengo,Alexandre A Loch,Wulf Rössler,Wagner F Gattaz
JMIR Mental Health. 2016; 3(3): e36
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223 Review of head-to-head study designs in rheumatoid arthritis
R Fleischmann,R Landewé,J Smolen
Seminars in Arthritis and Rheumatism. 2016;
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224 Brain and behavior changes associated with an abbreviated 4-week mindfulness-based stress reduction course in back pain patients
B. Blair Braden,Teri B. Pipe,Ryan Smith,Tyler K. Glaspy,Brandon R. Deatherage,Leslie C. Baxter
Brain and Behavior. 2016; : n/a
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225 Stepped Care Versus Direct Face-to-Face Cognitive Behavior Therapy for Social Anxiety Disorder and Panic Disorder: A Randomized Effectiveness Trial
Tine Nordgreen,Thomas Haug,Lars-Göran Öst,Gerhard Andersson,Per Carlbring,Gerd Kvale,Tone Tangen,Einar Heiervang,Odd E. Havik
Behavior Therapy. 2016; 47(2): 166
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226 A cluster randomized controlled trial of the Promoting Alternative Thinking Strategies (PATHS) curriculum
Neil Humphrey,Alexandra Barlow,Michael Wigelsworth,Ann Lendrum,Kirsty Pert,Craig Joyce,Emma Stephens,Lawrence Wo,Garry Squires,Kevin Woods,Rachel Calam,Alex Turner
Journal of School Psychology. 2016; 58: 73
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227 Service evaluation of an educational intervention to improve sexual health services in primary care implemented using a step-wedge design: analysis of chlamydia testing and diagnosis rate changes
Katy Town,Cliodna A. M. McNulty,Ellie J. Ricketts,Thomas Hartney,Anthony Nardone,Kate A. Folkard,Andre Charlett,J. Kevin Dunbar
BMC Public Health. 2016; 16(1)
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228 Implementing Family-Centered Prevention in Rural African American Communities: a Randomized Effectiveness Trial of the Strong African American Families Program
Steven M. Kogan,Man-Kit Lei,Gene H. Brody,Ted G. Futris,Megan Sperr,Tracy Anderson
Prevention Science. 2016; 17(2): 248
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229 Adherence adjustment in the Coronary Drug Project: A call for better per-protocol effect estimates in randomized trials
Eleanor J Murray,Miguel A Hernán
Clinical Trials. 2016; 13(4): 372
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230 Early goal-directed therapy in severe sepsis and septic shock: insights and comparisons to ProCESS, ProMISe, and ARISE
H. Bryant Nguyen,Anja Kathrin Jaehne,Namita Jayaprakash,Matthew W. Semler,Sara Hegab,Angel Coz Yataco,Geneva Tatem,Dhafer Salem,Steven Moore,Kamran Boka,Jasreen Kaur Gill,Jayna Gardner-Gray,Jacqueline Pflaum,Juan Pablo Domecq,Gina Hurst,Justin B. Belsky,Raymond Fowkes,Ronald B. Elkin,Steven Q. Simpson,Jay L. Falk,Daniel J. Singer,Emanuel P. Rivers
Critical Care. 2016; 20(1)
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231 Protocol of a randomized controlled trial of the fear of recurrence therapy (FORT) intervention for women with breast or gynecological cancer
Christine Maheu,Sophie Lebel,Christine Courbasson,Monique Lefebvre,Mina Singh,Lori J. Bernstein,Linda Muraca,Aronela Benea,Lynne Jolicoeur,Cheryl Harris,Agnihotram V. Ramanakumar,Sarah Ferguson,Souraya Sidani
BMC Cancer. 2016; 16(1)
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232 Effect of Domain Knowledge on Elicitation Effectiveness: An Internally Replicated Controlled Experiment
Alejandrina M. Aranda,Oscar Dieste,Natalia Juristo
IEEE Transactions on Software Engineering. 2016; 42(5): 427
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233 A Systematic Review Protocol to Assess the Effects of Physical Activity on Health and Quality of Life Outcomes in Adolescent Cancer Survivors
Amanda Wurz,Jennifer Brunet
JMIR Research Protocols. 2016; 5(1): e54
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234 Impact of adding a second layer to a single unlocked closure of a Cesarean uterine incision: randomized controlled trial
G. Bennich,M. Rudnicki,C. Wilken-Jensen,T. Lousen,P. D. Lassen,K. Wøjdemann
Ultrasound in Obstetrics & Gynecology. 2016; 47(4): 417
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235 Outcomes of Parathyroidectomy in Patients with Primary Hyperparathyroidism: A Systematic Review and Meta-analysis
Naykky M. Singh Ospina,Rene Rodriguez-Gutierrez,Spyridoula Maraka,Ana E. Espinosa de Ycaza,Sina Jasim,Ana Castaneda-Guarderas,Michael R. Gionfriddo,Alaa Al Nofal,Juan P. Brito,Patricia Erwin,Melanie Richards,Robert Wermers,Victor M. Montori
World Journal of Surgery. 2016;
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236 Medicaid Pay for Performance Programs and Childhood Immunization Status
Tianyan Hu,Sandra L. Decker,Shin-Yi Chou
American Journal of Preventive Medicine. 2016; 50(5): S51
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237 Forming a Stress Management and Health Promotion Program for Women Undergoing Chemotherapy for Breast Cancer
Panagiotis Pelekasis,Georgia Zisi,Anna Koumarianou,Androniki Marioli,George Chrousos,Konstantinos Syrigos,Christina Darviri
Integrative Cancer Therapies. 2016; 15(2): 165
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238 Progressive compression versus graduated compression for the management of venous insufficiency
Jan Shepherd
British Journal of Community Nursing. 2016; 21(Sup9): S13
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239 Sequential versus standard triple first-line therapy for Helicobacter pylori eradication
Olga P Nyssen,Adrian G McNicholl,Francis Megraud,Vincenzo Savarino,Giuseppina Oderda,Carlo A Fallone,Lori Fischbach,Franco Bazzoli,Javier P Gisbert
Cochrane Database of Systematic Reviews. 2016;
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240 Internet addiction and problematic Internet use: A systematic review of clinical research
Daria J Kuss,Olatz Lopez-Fernandez
World Journal of Psychiatry. 2016; 6(1): 143
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241 Do Web-based Mental Health Literacy Interventions Improve the Mental Health Literacy of Adult Consumers? Results From a Systematic Review
Bianca Brijnath,Joanne Protheroe,Kamal Ram Mahtani,Josefine Antoniades
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242 Exercise as a treatment for depression: A meta-analysis
Siri Kvam,Catrine Lykkedrang Kleppe,Inger Hilde Nordhus,Anders Hovland
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243 Injectable pharmacotherapy for opioid use disorders (IPOD)
David Farabee,Maureen Hillhouse,Timothy Condon,Barbara McCrady,Kathryn McCollister,Walter Ling
Contemporary Clinical Trials. 2016; 49: 70
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244 Evidence-based veterinary dermatology: a review of published studies of treatments forOtodectes cynotis(ear mite) infestation in cats
Ching Yang,Hui-Pi Huang
Veterinary Dermatology. 2016;
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245 A Pilot Study on the Efficacy of Volunteer Mentorship for Young Adults With Self-Harm Behaviors Using a Quasi-Experimental Design
Yik-Wa Law,Paul S. F. Yip,Carmen C. S. Lai,Chi Leung Kwok,Paul W. C. Wong,Kwong-Sun Liu,Pauline W. L. Ng,Carmen W. M. Liao,Tai-Wai Wong
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246 The Influence of Attrition in Evaluating the Efficacy and Effectiveness of Mindfulness-Based Interventions
Seungwon Nam,Tony Toneatto
International Journal of Mental Health and Addiction. 2016;
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247 Exercise as an intervention for first-episode psychosis: a feasibility study
Joseph Firth,Rebekah Carney,Rebecca Elliott,Paul French,Sophie Parker,Rebecca McIntyre,Jamie S. McPhee,Alison R. Yung
Early Intervention in Psychiatry. 2016; : n/a
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248 Statistical Primer on Biosimilar Clinical Development
Leah Isakov,Bo Jin,Ira Allen Jacobs
American Journal of Therapeutics. 2016; 23(6): e1903
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249 An Evaluation of Parent–Child Interaction Therapy With and Without Motivational Enhancement to Reduce Attrition
Haley J. Webb,Rae Thomas,Leanne McGregor,Elbina Avdagic,Melanie J. Zimmer-Gembeck
Journal of Clinical Child & Adolescent Psychology. 2016; : 1
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250 Development and Two-Year Follow-Up Evaluation of a Training Workshop for the Large Preventive Positive Psychology Happy Family Kitchen Project in Hong Kong
Agnes Y. Lai,Moses W. Mui,Alice Wan,Sunita M. Stewart,Carol Yew,Tai-hing Lam,Sophia S. Chan,Emmanuel Manalo
PLOS ONE. 2016; 11(1): e0147712
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251 Methodological issues in clinical trials of polycystic kidney disease: a focused review
Ioan-Andrei Iliuta,Abhijat Kitchlu,York Pei
Journal of Nephrology. 2016;
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252 Randomized Trials of the Teen Outreach Program in Louisiana and Rochester, New York
William T. Robinson,Susan M. Seibold-Simpson,Hugh F. Crean,Briana Spruille-White
American Journal of Public Health. 2016; 106(S1): S39
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253 Cost-effectiveness analysis of the single-implant mandibular overdenture versus conventional complete denture: study protocol for a randomized controlled trial
Túlio Eduardo Nogueira,Shahrokh Esfandiari,Cláudio Rodrigues Leles
Trials. 2016; 17(1)
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254 The Efficacy and Safety of Tetrachlorodecaoxide in Comparison with Super-oxidised Solution in Wound Healing
Romil Parikh,Girish Bakhshi,Madhushree Naik,Bhargav Gaikwad,Kavita Jadhav,Mukund Tayade
Archives of Plastic Surgery. 2016; 43(5): 395
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255 Cognitive remediation to enhance mobility in older adults: the CREM study
Joe Verghese,Emmeline Ayers,Jeannette R Mahoney,Anne Ambrose,Cuiling Wang,Roee Holtzer
Neurodegenerative Disease Management. 2016; 6(6): 457
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256 Exergaming for Health: A Randomized Study of Community-Based Exergaming Curriculum in Pediatric Weight Management
Amy L. Christison,Tyler A. Evans,Brandon B. Bleess,Huaping Wang,Jean C. Aldag,Helen J. Binns
Games for Health Journal. 2016; 5(6): 413
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257 Prostate cancer: Determining optimal therapy of early-stage disease remains complicated
David Canes
Nature Reviews Urology. 2016; 13(12): 703
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258 Can the provision of a home help service for the elderly population reduce the incidence of fall-related injuries? A quasi-experimental study of the community-level effects on hospital admissions in Swedish municipalities
Carl Bonander,Johanna Gustavsson,Finn Nilson
Injury Prevention. 2016; 22(6): 412
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259 Randomized Control Trial of Teaching Recovery Techniques in Rural Occupied Palestine: Effect on Adolescent Dissociation
Ian Barron,Ghassan Abdallah,Unni Heltne
Journal of Aggression, Maltreatment & Trauma. 2016; 25(9): 955
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260 Evaluation of the efficacy and safety of a standardised intracameral combination of mydriatics and anaesthetics for cataract surgery
Marc Labetoulle,Oliver Findl,François Malecaze,Jorge Alió,Béatrice Cochener,Conceição Lobo,Sihem Lazreg,Dahbia Hartani,Joseph Colin,Marie-José Tassignon,Anders Behndig
British Journal of Ophthalmology. 2016; 100(7): 976
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261 The longitudinal mental health benefits of a yoga intervention in women experiencing chronic stress: A clinical trial
Kaitlin N. Harkess,Paul Delfabbro,Sarah Cohen-Woods,Cornelia Duregger
Cogent Psychology. 2016; 3(1)
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262 Study protocol for a non-inferiority trial of a blended smoking cessation treatment versus face-to-face treatment (LiveSmokefree-Study)
Lutz Siemer,Marcel E. Pieterse,Marjolein G. J. Brusse-Keizer,Marloes G. Postel,Somaya Ben Allouch,Robbert Sanderman
BMC Public Health. 2016; 16(1)
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263 Effect of long-term vitamin E and selenium supplementation on urine F2-Isoprostanes, a biomarker of oxidative stress
Kristin A Guertin,Rachael K Grant,Kathryn B Arnold,Lindsay Burwell,JoAnn Hartline,Phyllis J Goodman,Lori M Minasian,Scott M Lippman,Eric Klein,Patricia A Cassano
Free Radical Biology and Medicine. 2016;
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264 Cost-Utility and Cost-Effectiveness Analyses of Face-to-Face Versus Telephone-Based Nonpharmacologic Multidisciplinary Treatments for Patients With Generalized Osteoarthritis
Nienke Cuperus,Wilbert B. van den Hout,Thomas J. Hoogeboom,Frank H. J. van den Hoogen,Thea P. M. Vliet Vlieland,Cornelia H. M. van den Ende
Arthritis Care & Research. 2016; 68(4): 502
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265 Invited review: Fermented milk as antihypertensive functional food
L.M. Beltrán-Barrientos,A. Hernández-Mendoza,M.J. Torres-Llanez,A.F. González-Córdova,B. Vallejo-Córdoba
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266 Self-training to improve UE function at the chronic stage post-stroke: a pilot randomized controlled trial
Debbie Rand,Harold Weingarden,Ronit Weiss,Anat Yacoby,Shlomit Reif,Rachel Malka,David Andrew Shiller,Gabi Zeilig
Disability and Rehabilitation. 2016; : 1
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267 Data Blind Review and Analysis Set in Clinical Trial
Chiyeon Lim,Minjung Kwak
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268 Using Alcohol Unit-marked Glasses Enhances Capacity To Monitor Intake: Evidence From a Mixed-method Intervention Trial
Richard de Visser,Clare Brown,Richard Cooke,Greg Cooper,Anjum Memon
Alcohol and Alcoholism. 2016;
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269 Increasing patient involvement in the diabetic foot pathway: a pilot randomized controlled trial
E. McBride,B. Hacking,R. OæCarroll,M. Young,J. Jahr,C. Borthwick,A. Callander,Z. Berrada
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270 Post-instrumentation pain after the use of either Mtwo or the SAF system: a randomized controlled clinical trial
P. Saumya-Rajesh,J. Krithikadatta,N. Velmurugan,C. Sooriaprakas
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271 Study protocol: a cluster randomized controlled trial to assess the effectiveness of a multi-pronged behavioural intervention to improve use of personal protective equipment among migrant workers exposed to organic solvents in small and medium-sized enterprises
Wen Chen,Tongyang Li,Guanyang Zou,Xudong Li,Leiyu Shi,Shanshan Feng,Jingrong Shi,Fangjing Zhou,Siqi Han,Li Ling
BMC Public Health. 2016; 16(1)
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272 An Overview of Challenges and Approaches to Minimize Bias in Randomized Controlled Trials in Perioperative Medicine
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273 Comparative effectiveness and safety of antipsychotic drugs in schizophrenia treatment: a real-world observational study
A. Vanasse,L. Blais,J. Courteau,A. A. Cohen,P. Roberge,A. Larouche,S. Grignon,M.-J. Fleury,A. Lesage,M.-F. Demers,M.-A. Roy,J.-D. Carrier,A. Delorme
Acta Psychiatrica Scandinavica. 2016;
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274 Effects of Internet-Based Self-Efficacy Intervention on Secondary Traumatic Stress and Secondary Posttraumatic Growth among Health and Human Services Professionals Exposed to Indirect Trauma
Roman Cieslak,Charles C. Benight,Anna Rogala,Ewelina Smoktunowicz,Martyna Kowalska,Katarzyna Zukowska,Carolyn Yeager,Aleksandra Luszczynska
Frontiers in Psychology. 2016; 7
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275 Family-centred music therapy with preterm infants and their parents in the Neonatal Intensive Care Unit (NICU) in Colombia – A mixed-methods study
Mark Ettenberger,Catherine Rojas Cárdenas,Mike Parker,Helen Odell-Miller
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276 Evaluating the effectiveness of combining home-start and triple P parenting support in the Netherlands
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277 The impact of trial stage, developer involvement and international transferability on universal social and emotional learning programme outcomes: a meta-analysis
M. Wigelsworth,A. Lendrum,J. Oldfield,A. Scott,I. ten Bokkel,K. Tate,C. Emery
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278 Preliminary study of a rehabilitation program based on attentional processes to treat auditory hallucinations
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Cognitive Neuropsychiatry. 2016; : 1
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279 Systematic Review of Yoga Interventions to Promote Cardiovascular Health in Older Adults
Jennifer L. Barrows,Julie Fleury
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280 The effect of supervised and home based exercises on balance in elderly subjects: a randomized controlled trial to prevent falls
Erika Harumi Tanaka,Paulo Ferreira dos Santos,Marcela Fernandes Silva,Priscila Fernanda Figueiredo Borges Botelho,Patrícia Silva,Natalia Camargo Rodrigues,Matheus Machado Gomes,Renato Moraes,Daniela Cristina Carvalho de Abreu
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281 Study protocol RapMusicTherapy for emotion regulation in a school setting
Sylka Uhlig,Erik Jansen,Erik Scherder
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282 Preliminary evaluation of a self-directed video-based 1-2-3 Magic parenting program: A randomized controlled trial
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Behaviour Research and Therapy. 2015;
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283 Whole-grain wheat consumption reduces inflammation in a randomized controlled trial on overweight and obese subjects with unhealthy dietary and lifestyle behaviors: role of polyphenols bound to cereal dietary fiber
Paola Vitaglione,Ilario Mennella,Rosalia Ferracane,Angela A Rivellese,Rosalba Giacco,Danilo Ercolini,Sean M Gibbons,Antonietta La Storia,Jack A Gilbert,Satya Jonnalagadda,Frank Thielecke,Maria A Gallo,Luca Scalfi,Vincenzo Fogliano
The American Journal of Clinical Nutrition. 2015; 101(2): 251
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284 Intravenous estrogen is not proven effective for abnormal uterine bleeding: guidelines are based on flawed evidence
Stephen Simmer
Clinical Research in Practice: The Journal of Team Hippocrates. 2015; 1(1): 1
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285 Development and Assessment of an E-Learning Course on Breast Imaging for Radiographers: A Stratified Randomized Controlled Trial
Inês C Moreira,Sandra Rua Ventura,Isabel Ramos,Pedro Pereira Rodrigues
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286 Taking the next step: a systematic review and meta-analysis of physical activity and behavior change interventions in recent post-treatment breast cancer survivors
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287 Evaluation of the implementation and impact of an integrated prevention model on the academic progress of students with disabilities
Alexandra Barlow,Neil Humphrey,Ann Lendrum,Michael Wigelsworth,Garry Squires
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288 Time at Risk and Intention-to-treat Analyses
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289 Early Pathways Therapy for Young Children in Poverty
Sara E. Harris,Robert A. Fox,Joanna R. Love
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290 Web-based interventions for comorbid depression and chronic illness: a systematic review
Ekaterina Charova,Diana Dorstyn,Phillip Tully,Oskar Mittag
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291 Telepsychology for Posttraumatic Stress Disorder: A systematic review
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292 A web-based personally controlled health management system increases sexually transmitted infection screening rates in young people: a randomized controlled trial
Nathan J Mortimer,Joel Rhee,Rebecca Guy,Andrew Hayen,Annie Y S Lau
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293 Intervention Mapping to Adapt Evidence-Based Interventions for Use in Practice: Increasing Mammography among African American Women
Linda Highfield,Marieke A. Hartman,Patricia Dolan Mullen,Serena A. Rodriguez,Maria E. Fernandez,L. Kay Bartholomew
BioMed Research International. 2015; 2015: 1
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294 Whoæs Missing? Predictors of Attrition Following Participation in Culturally Targeted Educational Breast and Cervical Cancer Outreach Programs for Latinas
Jamilia Sly,Lina Jandorf,Deborah O. Erwin
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295 Multisystemic Therapy Improves the Patient-Provider Relationship in Families of Adolescents with Poorly Controlled Insulin Dependent Diabetes
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296 Assessing the treatment effect in a randomized controlled trial with extensive non-adherence: the EVOLVE trial
Yumi Kubo,Lulu Ren Sterling,Patrick S Parfrey,Karminder Gill,Kenneth W Mahaffey,Ioanna Gioni,Marie-Louise Trotman,Bastian Dehmel,Glenn M Chertow
Pharmaceutical Statistics. 2015; 14(3): 242
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297 Randomized trial of the effectiveness of a non-pharmacological multidisciplinary face-to-face treatment program on daily function compared to a telephone-based treatment program in patients with generalized osteoarthritis
N. Cuperus,T.J. Hoogeboom,C.C. Kersten,A.A. den Broeder,T.P.M. Vliet Vlieland,C.H.M. van den Ende
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298 A practice-based randomized controlled trial to improve medication adherence among Latinos with hypertension: study protocol for a randomized controlled trial
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Trials. 2015; 16(1)
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299 Considerations for Comprehensive Analyses of Sporozoite-Based Controlled Human Malaria Infection Studies
Andrew A. Lover
The American Journal of Tropical Medicine and Hygiene. 2015; 93(6): 1130
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300 A randomized controlled trial of a multi-dose bystander intervention program using peer education theater
Sarah McMahon,Samantha C. Winter,Jane E. Palmer,Judy L. Postmus,N. Andrew Peterson,Sharon Zucker,RuthAnne Koenick
Health Education Research. 2015; 30(4): 554
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301 Supporting Practices to Adopt Registry-Based Care (SPARC): protocol for a randomized controlled trial
Rebecca S Etz,Rosalind E Keith,Anna M Maternick,Karen L Stein,Roy T Sabo,Melissa S Hayes,Purvi Sevak,John Holland,Jesse C Crosson
Implementation Science. 2015; 10(1)
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302 Effect of the probiotic strain Bifidobacterium animalis subsp. lactis, BB-12®, on defecation frequency in healthy subjects with low defecation frequency and abdominal discomfort: a randomised, double-blind, placebo-controlled, parallel-group trial
Dorte Eskesen,Lillian Jespersen,Birgit Michelsen,Peter J. Whorwell,Stefan Müller-Lissner,Cathrine M. Morberg
British Journal of Nutrition. 2015; 114(10): 1638
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303 General or Spinal Anaesthetic for Vaginal Surgery in Pelvic Floor Disorders (GOSSIP): a feasibility randomised controlled trial
B. Purwar,K. M. Ismail,N. Turner,A. Farrell,M. Verzune,M. Annappa,I. Smith,Zeiad El-Gizawy,J. C. Cooper
International Urogynecology Journal. 2015; 26(8): 1171
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304 Effect of exercises with weight vests and a patient education programme for women with osteopenia and a healed wrist fracture: a randomized, controlled trial of the OsteoACTIVE programme
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BMC Musculoskeletal Disorders. 2015; 16(1)
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305 Evaluation of a hybrid treatment for Veterans with comorbid traumatic brain injury and posttraumatic stress disorder: Study protocol for a randomized controlled trial
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306 Randomized Controlled Trial of an Internet Application to Reduce HIV Transmission Behavior Among HIV Infected Men Who have Sex with Men
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AIDS and Behavior. 2015;
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307 Home-based virtual reality balance training and conventional balance training in Parkinsonæs disease: A randomized controlled trial
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308 Effect of an integrated community-based package for maternal and newborn care on feeding patterns during the first 12 weeks of life: a cluster-randomized trial in a South African township
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309 Effectiveness of Conventional Versus Virtual Reality–Based Balance Exercises in Vestibular Rehabilitation for Unilateral Peripheral Vestibular Loss: Results of a Randomized Controlled Trial
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Archives of Physical Medicine and Rehabilitation. 2015; 96(7): 1319
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310 FAmily CEntered (FACE) advance care planning: Study design and methods for a patient-centered communication and decision-making intervention for patients with HIV/AIDS and their surrogate decision-makers
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311 Caring for the carer: a systematic review of pure technology-based cognitive behavioral therapy (TB-CBT) interventions for dementia carers
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Aging & Mental Health. 2015; : 1
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312 A Preliminary Evaluation of the 1-2-3-Magic Parenting Program in an Australian Community Services Setting
Renata Porzig-Drummond,Richard J. Stevenson,Caroline Stevenson
Australian Social Work. 2015; : 1
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313 The Effectiveness of the Within Our Reach Relationship Education Program for Couples: Findings from a Federal Randomized Trial
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314 Evaluation of the Effectiveness and Implementation of an Adapted Evidence-Based Mammography Intervention for African American Women
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315 Does neurocognitive training have the potential to improve dietary self-care in type 2 diabetes? Study protocol of a double-blind randomised controlled trial
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316 Re: Pareek A, Chandurkar N, Thomas N,et al.Efficacy and safety of hydroxychloroquine in the treatment of type 2 diabetes mellitus: a double blind, randomized comparison with pioglitazone. Curr Med Res Opin 2014;30:1257-66
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317 A Randomized Controlled Trial of a Financial Literacy Curriculum for Survivors of Intimate Partner Violence
Andrea Hetling,Judy L. Postmus,Cecilia Kaltz
Journal of Family and Economic Issues. 2015;
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318 Passive standing as an adjunct rehabilitation intervention after stroke: a randomized controlled trial
Francesco Ferrarello,Gabriella Deluca,Assunta Pizzi,Carlo Baldini,Francesca Iori,Niccolò Marchionni,Mauro Di Bari
Archives of Physiotherapy. 2015; 5(1)
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319 Prolonged Exposure for Treating PTSD Among Female Methadone Patients Who Were Survivors of Sexual Abuse in Israel
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Social Work in Health Care. 2015; 54(8): 687
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320 Effects of a brief mindfulness-based intervention program for stress management among medical students: the Mindful-Gym randomized controlled study
Cheng Kar Phang,Firdaus Mukhtar,Normala Ibrahim,Shian-Ling Keng,Sherina Mohd. Sidik
Advances in Health Sciences Education. 2015; 20(5): 1115
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321 Radiofrequency catheter ablation maintains its efficacy better than antiarrhythmic medication in patients with paroxysmal atrial fibrillation: On-treatment analysis of the randomized controlled MANTRA-PAF trial
M.J. Pekka Raatikainen,Antti Hakalahti,Paavo Uusimaa,Jens Cosedis Nielsen,Arne Johannessen,Gerhard Hindricks,Håkan Walfridsson,Steen Pehrson,Anders Englund,Juha Hartikainen,Ole Kongstad,Leif Spange Mortensen,Peter Steen Hansen
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322 Interest in Employment Among People with Schizophrenia
Cassandra Westcott,Geoffrey Waghorn,Duncan McLean,Dixie Statham,Bryan Mowry
American Journal of Psychiatric Rehabilitation. 2015; 18(2): 187
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323 Use of mouth rinse during pregnancy to improve birth and neonatal outcomes: a randomized controlled trial
Hong Jiang,Xu Xiong,Pierre Buekens,Yi Su,Xu Qian
BMC Pregnancy and Childbirth. 2015; 15(1)
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324 Effect of Developmental Binocular Vision Abnormalities on Visual Vertigo Symptoms and Treatment Outcome
Marousa Pavlou,James Acheson,Despina Nicolaou,Clare L. Fraser,Adolfo M. Bronstein,Rosalyn A. Davies
Journal of Neurologic Physical Therapy. 2015; 39(4): 215
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325 The Integration of Family and Group Therapy as an Alternative to Juvenile Incarceration: A Quasi-Experimental Evaluation Using Parenting with Love and Limits
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Family Process. 2015; : n/a
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326 Effective Implementation Strategies of Differential Response in Child Welfare: A Comparative Case Analysis
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327 Look for good and never give up: A novel attention training treatment for childhood anxiety disorders
Allison M. Waters,Melanie J. Zimmer-Gembeck,Michelle G. Craske,Daniel S. Pine,Brendan P. Bradley,Karin Mogg
Behaviour Research and Therapy. 2015; 73: 111
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328 Effect of Deep Intramuscular Stimulation and Transcranial Magnetic Stimulation on Neurophysiological Biomarkers in Chronic Myofascial Pain Syndrome
Liciane F. Medeiros,Wolnei Caumo,Jairo Dussán-Sarria,Alicia Deitos,Aline Brietzke,Gabriela Laste,Cristina Campos-Carraro,Andressa de Souza,Vanessa L. Scarabelot,Stefania G. Cioato,Rafael Vercelino,Alexandre L. de Castro,Alex Sander Araújo,Adriane Belló-Klein,Felipe Fregni,Iraci L.S. Torres
Pain Medicine. 2015; : n/a
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329 Who responds to financial incentives for weight loss? Evidence from a randomized controlled trial
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330 RE
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331 Iyengar Yoga for Adolescents and Young Adults With Irritable Bowel Syndrome
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332 The Digital Divide and Health Disparities: a Pilot Study Examining the Use of Short Message Service (SMS) for Colonoscopy Reminders
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333 Teaching Biomedical Statistics to Nurse-Practitioners in Sub-Saharan Africa—The Example of “Intention to Treat” Shows Our Challenges and Dilemmas
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334 Impact of checklists on peri-intubation care in Emergency Department trauma patients
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335 A 7-day oral supplementation with branched-chain amino acids was ineffective to prevent muscle damage during a marathon
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336 Evaluation of the making sense of brain tumor program: a randomized controlled trial of a home-based psychosocial intervention
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Psycho-Oncology. 2014; : n/a
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337 A multi-site randomised controlled trial of evidence-based supported employment for adults with severe and persistent mental illness
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Australian Occupational Therapy Journal. 2014; : n/a
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338 Low- Versus High-Dose Rituximab for Rheumatoid Arthritis: A Systematic Review and Meta-Analysis
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339 Impact of an Exercise Intervention on Physical Activity During Pregnancy: The Behaviors Affecting Baby and You Study
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340 Effects of a 12-week endurance training program on the physiological response to psychosocial stress in men: a randomized controlled trial
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341 Early intervention in psychosis: a feasibility study financed by the Italian Center on Control of Maladies
Angelo Cocchi,Andrea Balbi,Giuseppe Corlito,Guido Ditta,Walter Di Munzio,Mario Nicotera,Anna Meneghelli,Alessia Pisano,Antonio Preti
Early Intervention in Psychiatry. 2014; : n/a
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342 Effects of yoga on stress and inflammatory factors in patients with chronic low back pain: A non-randomized controlled study
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343 Intervention Effects on Adolescent Physical Activity in the Multicomponent SPACE Study: A Cluster Randomized Controlled Trial
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344 Quality of Reporting Randomized Controlled Trials in Cancer Nursing Research
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Nursing Research. 2014; 63(1): 26
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345 Transobturator Sling Compared With Single-Incision Mini-Sling for the Treatment of Stress Urinary Incontinence
Lucyana M. Djehdian,Maita P. Araujo,Claudia C. Takano,Carlos A. Del-Roy,Marair G. F. Sartori,Manoel J. B. C. Girão,Rodrigo A. Castro
Obstetrics & Gynecology. 2014; 123(3): 553
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346 Central Retinal Enrichment Supplementation Trials (CREST): Design and Methodology of the CREST Randomized Controlled Trials
Kwadwo Owusu Akuffo,Stephen Beatty,Jim Stack,Jessica Dennison,Sarah O’Regan,Katherine A. Meagher,Tunde Peto,John Nolan
Ophthalmic Epidemiology. 2014; 21(2): 111
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347 Zanamivir versus trivalent split virus influenza vaccine: a pilot randomized trial
Brenda L. Coleman,Shaza A. Fadel,Steven J. Drews,Todd F. Hatchette,Allison J. McGeer
Influenza and Other Respiratory Viruses. 2014; : n/a
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348 Efficacy of Omeprazole Powder Paste or Enteric-Coated Formulation in Healing of Gastric Ulcers in Horses
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349 Title and Abstract Screening and Evaluation in Systematic Reviews (TASER): a pilot randomised controlled trial of title and abstract screening by medical students
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350 The effect of continuous passive motion and sling exercise training on clinical and functional outcomes following total knee arthroplasty: a randomized active-controlled clinical study
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351 Effectiveness of the Dader Method for pharmaceutical care in patients with bipolar I disorder: EMDADER-TAB: study protocol for a randomized controlled trial
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352 How much did Chinaæs WTO accession increase economic growth in resource-rich countries?
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353 The 1-2-3 Magic Parenting Program and its Effect on Child Problem Behaviors and Dysfunctional Parenting: A Randomized Controlled Trial
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Behaviour Research and Therapy. 2014;
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354 Occupational Performance Coaching for stroke survivors: A pilot randomized controlled trial protocol
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355 New Information Prompts Old Question: Is Sentinel Lymph Node Sampling Equivalent to Axillary Lymph Node Dissection?
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356 Reducing the risk of bias in health behaviour change trials: Improving trial design, reporting or bias assessment criteria? A review and case study
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357 Acupressure for agitation in nursing home residents with dementia: study protocol for a randomized controlled trial
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358 Comment on: Bari-Active: a randomized controlled trial of a preoperative intervention to increase physical activity in bariatric surgery patients
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359 A randomized controlled trial of pre-conception treatment for periodontal disease to improve periodontal status during pregnancy and birth outcomes
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360 Anesthesia Induction Using Video Glasses as a Distraction Tool for the Management of Preoperative Anxiety in Children
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361 Unresectable Hepatocellular Carcinoma: Randomized Controlled Trial of Transarterial Ethanol Ablation versus Transcatheter Arterial Chemoembolization
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362 Dysphonia in preterm children: Assessing incidence and response to treatment
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363 Effect of different statistical methods on union or time to union in a published study about clavicular fractures
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364 Comparison of error-based and errorless learning for people with severe traumatic brain injury: study protocol for a randomized control trial
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365 A meta-analytic review of exposure in group cognitive behavioral therapy for posttraumatic stress disorder
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366 Meta-analysis: pharmacological treatment of pathological gambling
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367 How to appraise a randomized controlled trial
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368 Real-world utilization patterns and outcomes of colesevelam hcl in the ge electronic medical record
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369 Taking Financial Relationships into Account When Assessing Research
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370 The effectiveness of therapeutic exercise for joint hypermobility syndrome: a systematic review
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371 Unresectable Hepatocellular Carcinoma: Randomized Controlled Trial of Transarterial Ethanol Ablation versus Transcatheter Arterial Chemoembolization
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372 Adjuvant Chemotherapy in Invasive Bladder Cancer: 2013 Updated Systematic Review and Meta-Analysis of Randomized Trials
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373 Outcomes Monitoring and Implementing Evidence-Based Nutrition Practice Guidelines for Type 2 Diabetes Mellitus in 2 Middle Eastern Countries
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374 Prospective, Randomized, Blinded, Comparative Study of Injectable Micronized Dehydrated Amniotic/Chorionic Membrane Allograft for Plantar Fasciitis—A Feasibility Study
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375 Misconduct versus Honest Error and Scientific Disagreement
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376 Cost-effectiveness of intermittent preventive treatment of malaria in infants (IPTi) for averting anaemia in Gabon: a comparison between intention to treat and according to protocol analyses
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