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ORIGINAL ARTICLE
Year : 2012  |  Volume : 3  |  Issue : 4  |  Page : 139-142

A study on prescribing patterns of antihypertensives in geriatric patients


1 Department of Pharmacy Practice and Pharm D, St. Peter's Institute of Pharmaceutical Sciences, Kakatiya University, Warangal - 506 001, Andhra Pradesh, India
2 Department of General Medicine, Rohini Super Specialty Hospital, Warangal - 506 001, Andhra Pradesh, India

Date of Web Publication19-Nov-2012

Correspondence Address:
Uday V Mateti
Department of Pharmacy Practice and Pharm D, St. Peter's Institute of Pharmaceutical Sciences, Rohini Super Specialty Hospital, Kakatiya University, Warangal - 506 001, Andhra Pradesh
India
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DOI: 10.4103/2229-3485.103595

PMID: 23293761

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   Abstract 

Objective: Hypertension is a leading contributor to the global burden of cardiovascular morbidity and mortality. The main objective of the present study was to assess the prescribing patterns for antihypertensives in geriatric patients. Materials and Methods: A Prospective observational study was carried out for the period of six months in an out-patient department. Elderly patients who have been diagnosed with hypertension as per JNC-7 guidelines and patients receiving or prescribed with antihypertensive drugs were included. Results: A total of 100 prescriptions were analyzed during the six-month study period. 72% of the patients were in the age group of 65-67 years and this was found to be higher in men 69%. During the study period 80% of the patients were Pre-Hypertensive systolic (80-89 mmHg) and Diastolic (120-139 mmHg) followed by Stage-I Hypertension and Stage-II Hypertension. The most common drug classes involved in the study was Calcium Channel Blockers 37% followed by Angiotensin II receptor antagonists 21% and the most commonly prescribed drugs in the study population were Amlodipine 37%, Losartan 11% and Telmisartan 10%. The most common anti-hypertensive fixed dose combination therapy involved in the study was Telmisartan + Hydrochlorothiazide 15% and most common two drug combination therapy involved in the study was Amlodipine + Atenolol 7% followed by Metoprolol + Amlodipine 1%. Conclusion: Our study shows that the most commonly prescribed drug classes involved were Calcium Channel Blockers followed by Angiotensin II receptor antagonists and the anti-hypertensive drug combinations among hypertensive patients were considerable and this practice positively impacted on the overall blood pressure control.

Keywords: Anti-hypertensives, blood pressure, geriatrics, JNC-7


How to cite this article:
Mohd AH, Mateti UV, Konuru V, Parmar MY, Kunduru BR. A study on prescribing patterns of antihypertensives in geriatric patients. Perspect Clin Res 2012;3:139-42

How to cite this URL:
Mohd AH, Mateti UV, Konuru V, Parmar MY, Kunduru BR. A study on prescribing patterns of antihypertensives in geriatric patients. Perspect Clin Res [serial online] 2012 [cited 2014 Nov 27];3:139-42. Available from: http://www.picronline.org/text.asp?2012/3/4/139/103595


   Introduction Top


Hypertension is a leading contributor to the global burden of cardiovascular morbidity and mortality. Prevalence of hypertension in India in 2000 was 60.4 million males and 57.8 million females and projected to increase to 107.3 million and 106.2 million respectively in 2025. Hypertension is vary from 4-15% in urban and 2-8% in rural population. [1] Apart from unhealthy lifestyles, lack of awareness about hypertension, distorted public health systems, physicians treating hypertension also lag behind in treating hypertension according to standard guidelines. Non compliance to antihypertensive therapy is also a reason for uncontrolled hypertension. [2] Elderly patients commonly have multiple pathologies leading to polypharmacy, and altered pharmacokinetics and pharmacodynamics, are prone to adverse drug reactions from inappropriate medication. [3],[4] At least high normal blood pressure (below 140/90 mmHg) in elderly patients as mentioned in the Indian Hypertension Guidelines II. [5] The main objective of the present study is to assess the prescribing patterns for antihypertensives in geriatric patients.


   Materials and Methods Top


A Prospective observational study was carried out for the period of six months (January 2011- June 2011) in an out-patient department of Rohini Superspeciality Hospital. It is a 300-bedded Hospital situated in the heart of city at Warangal, Andhra Pradesh. Ethical approval was obtained from the institutional and hospital committee prior to study initiation. Elderly patients of age >65 years who have been diagnosed with hypertension as per JNC-7 guidelines and patients receiving or prescribed with antihypertensive drugs were included. [6] Details necessary for evaluation regarding chief complaints of the patients, previous allergies, comorbidities, and others were collected from the patient's clinical records. Certain demographic characteristics were studied and the factors studied were: (a) patient characteristics [gender, age (>65 years), and comorbidities], (b) drug characteristics [list of antihypertensive and number of drugs prescribed] and Blood Pressure. The Sociodemographic status such as educational qualification, occupation, monthly income, and social habits of the patients were collected. All data were collected from data collection form, and to review the current prescribing patterns of Anti-hypertensive drugs in hypertension patients with co-morbidities and without co-morbidities, use of Anti-Hypertensive Drug Monotherapy and combination therapy in patient with hypertension.


   Results Top


A total of 100 patients were consulted during the six-month study period, in an out-patient department at Rohini Superspeciality Hospital. Of these 100 prescriptions, 72% of the patients were in the age group of 65-67 years, followed by 26% in 68-70 years and 2% who were >70 years, and this was found to be higher in men 69% than in women 31%. The numbers of drugs prescribed were in the range of 4-6 per prescription. The Sociodemographic status such as Educational qualification, Occupation, Monthly Income, and Social habits of the patients was summarized in [Table 1]. Hypertensive patients were classified on the basis of Joint National Committee (JNC-7) was summarized in [Table 2].
Table 1: Sociodemographic status of the patients

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Table 2: Classification of hypertensive patients on the basis of JNC-7

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The most common drug classes involved in the study was Calcium Channel Blockers 37% followed by Angiotensin II receptor antagonists 21%, and other prescribing patterns of Anti-Hypertensive Drug Monotherapy were summarized in [Table 3]. The most common anti-hypertensive fixed dose combination therapy involved in the study was Telmisartan + Hydrochlorothiazide 15% followed by Olmesartan + Hydrochlorothiazide 3%, Losartan + Hydrochlorothiazide 1% and Ramipril + Hydrochlorothiazide 1%. The most common two drug combination therapy involved in the study was Amlodipine + Atenolol 7% followed by Metoprolol + Amlodipine 1%. Prescribing patterns of antihypertensive were classified into two types like with comorbidities 38%, and without comorbidities 62%. Among these comorbidities Cerebrovascular Accident Hemiplegia 21%, Diabetic Mellitus 13%, Diabetic Mellitus + Hemiplegia 4% and the detailed drugs prescribed with comorbid conditions were summarized in [Table 4]. Among these without comorbidities were divided into two types of drugs prescribed with single drug 39% and combination drug therapy 23%, these results were summarized in [Table 5].
Table 3: Prescription pattern of anti-Hypertensive drug monotherapy

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Table 4: Use of anti-hypertensive drugs in hypertension patients with co-morbidities

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Table 5: Use of Anti-hypertensive drugs in hypertension patients with no co-morbidities

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   Discussion Top


With increasing economic growth rate, India is not only facing the epidemic of Coronary Artery Disease but also of obesity, diabetes mellitus, and hypertension. Prevalence of hypertension has remained stable or has decreased in developed countries during the past decade; it has dramatically increased in developing countries like India. [6],[7] Our finding shows that the prescribing patterns of anti-hypertensive drugs in geriatrics out-patient department during the study period was found to be higher in men 69% than in women 31%. High blood pressure is more common in men then women. The women's were more likely to develop high blood pressure after menopause. [6] The risk of high blood pressure increases with age and in the early middle age. [4],[6],[8] In the present study 76% of the patients were Literate, 57% were employed, 31% of the patients having the monthly income of 5000-10000 and 20% were smokers and 15% were alcoholic patients. During the study period 80% of the patients were Pre-Hypertensive systolic (80-89 mmHg) and Diastolic (120-139 mmHg) followed by Stage-I Hypertension and Stage-II Hypertension.

The most commonly prescribed drug classes involved in the study was Calcium Channel Blockers 37% followed by Angiotensin II receptor antagonists 21% and the most commonly prescribed drugs in the study population were Amlodipine 37%, Losartan 11% and Telmisartan 10%. These results were compared with Datta S et al., and Almas A et al., conducted at tertiary care hospital shown that Calcium Channel Blocker- Amlodipine is the most commonly used antihypertensive monotherapy and Neal B et al., study results shown that the strong evidence of benefits of calcium antagonists is provided by the overviews of placebo-controlled trials. [9],[10],[11],[12] The most common anti-hypertensive fixed dose combination therapy involved in the study was Telmisartan + Hydrochlorothiazide 15% and most common two drug combination therapy involved in the study was Amlodipine + Atenolol 7% followed by Metoprolol + Amlodipine 1% and these findings were not comparable with the studies conducted at tertiary care hospital beta blockers is used as the most common combination therapy. [9],[10] Prescribing patterns of antihypertensive were classified into two types like with comorbidities 38%, and without comorbidities 62%. Among these comorbidities Cerebrovascular Accident Hemiplegia 21%, Diabetic Mellitus 13%, Diabetic Mellitus + Hemiplegia 4%.


   Conclusion Top


Our study shows that the most commonly prescribed drug classes involved were Calcium Channel Blockers followed by Angiotensin II receptor antagonists and the anti-hypertensive drug combinations among hypertensive patients were considerable and this practice positively impacted on the overall blood pressure control. In order to promote the rational prescribing drugs and hospital formularies in special committees are useful in reducing the misuse of drugs especially in poly-pharmacy and in the treatment of hypertension.

 
   References Top

1.Lawes CM, Vander HS, Rodgers A. Global burden of blood-pressure related disease, 2001. Lancet 2008;371:1513-8.  Back to cited text no. 1
    
2.Egan BM, Zhao Y, Axon RN. US trends in prevalence, awareness, treatment, and control of hypertension, 1988-2008. JAMA 2010;303: 2043-50.  Back to cited text no. 2
[PUBMED]    
3.Cunningham G, Dodd TR, Grant DJ, Murdo ME, Richards RM. Drug-related problems in elderly patients admitted to Tayside hospitals, methods for prevention and subsequent reassessment. Age Ageing 1997;26:375-82.  Back to cited text no. 3
[PUBMED]    
4.Mannesse CK, Derkx FH, Ridder MA, Man Veld AJ, Van D, Cammen TJ. Adverse drug reactions in elderly patients as contributing factor for hospital admission: Cross sectional study. BMJ 1997;315:1057-8.  Back to cited text no. 4
    
5.Chobanian AV, Bakris GL, Black HR, Cushman WC, Green LA, Izzo JL Jr, et al. The seventh report of the joint national committee on prevention, detection, evaluation, and treatment of high blood pressure: The JNC 7 report. JAMA 2003;289:2560-72.  Back to cited text no. 5
[PUBMED]    
6.Psaty BM, Lumley T, Furberg CD, Schellenbaum G, Pahor M, Alderman MH, et al. Health outcomes associated with antihypertensive therapies used as first-line agents. A systematic review and meta-analysis. JAMA 1997;277:739-45.  Back to cited text no. 6
[PUBMED]    
7.Chaturvedi M, Jindal S, Kumar R. Lifestyle modification in hypertension in the Indian context. J Indian Acad Commun Med 2009;10:46-51.  Back to cited text no. 7
    
8.MacMahon S, Rodgers A. The effects of blood pressure reduction in older patients: An overview of five randomised controlled trials in elderly hypertensives. Clin Exp Hypertens 1993;15:967-78.  Back to cited text no. 8
[PUBMED]    
9.Datta S, Sharma C. Prescribing pattern of antihypertensives in patients having comorbid ischemic heart disease: Study in a tertiary care hospital. J Pharm Res 2010;3:2142-4.  Back to cited text no. 9
    
10.Datta S. Use of antihypertensives in patients having associated renal parenchymal disorders: Cross sectional prescription pattern study in a tertiary care hospital. Int J Pharm Sci Drug Res 2011;3:256-9.  Back to cited text no. 10
    
11.Almas A, Salik RI, Ehtamam A, Khan AH. Spectrum of antihypertensive therapy in south Asians at a tertiary care hospital in Pakistan. BMC Res Notes 2011;4:318.  Back to cited text no. 11
    
12.Neal B, MacMahon S, Chapman N. Effects of ACE inhibitors, calcium antagonists, and other blood-pressure lowering drugs: Results of prospectively designed overviews of randomised trials. Blood pressure lowering treatment trialists' collaboration. Lancet 2000;356:1955-64.  Back to cited text no. 12
    



 
 
    Tables

  [Table 1], [Table 2], [Table 3], [Table 4], [Table 5]


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