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RESEARCH METHODOLOGY
Year : 2014  |  Volume : 5  |  Issue : 2  |  Page : 88-90

Up-dosing of non-sedating antihistamines in chronic urticaria: Need for well-designed clinical trials in India


Freelance Consultant: Medical Communication and Training, Navi Mumbai, India

Correspondence Address:
Anant D Patil
B-101, Balaji Bhavan CHS, Sector 44 A, Nerul, Mumbai, Maharashtra
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2229-3485.128029

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Urticaria is a heterogeneous group of diseases. Chronic urticaria significantly impacts quality-of-life of patients. Second generation, non-sedating antihistamines are recommended as first line treatment for chronic spontaneous urticaria. In patients with inadequate control of symptoms, increase in dosage of non-sedating antihistamines up to four fold has been recommended. This recommendation is based on low cost, good safety and good evidence of efficacy of non-sedating, second generation antihistamines. This article reviewed Indian data on up-dosing of antihistamines in chronic urticaria. There is a need for well-designed clinical trials with ­up-dosing of individual antihistamines in Indian patients.


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