|Year : 2015 | Volume
| Issue : 2 | Page : 86-90
A systematic review of prescription pattern monitoring studies and their effectiveness in promoting rational use of medicines
Shipra Jain1, Prerna Upadhyaya1, Jaswant Goyal1, Kumar Abhijit1, Pushpawati Jain1, Vikas Seth2, Vijay V Moghe3
1 Department of Pharmacology, Mahatma Gandhi Medical College and Hospital, Jaipur, Rajasthan, India
2 Department of Pharmacology, Mayo Institute of Medical Sciences, Gadia, Barabanki, Uttar Pradesh, India
3 Department of Pharmacology, Terna Medical College, Nerul, Navi Mumbai, Mumbai, Maharashtra, India
|Date of Web Publication||26-Mar-2015|
Department of Pharmacology, Mahatma Gandhi Medical College and Hospital, Jaipur, Rajasthan
Source of Support: None, Conflict of Interest: None
| Abstract|| |
Prescription pattern monitoring studies (PPMS) are a tool for assessing the prescribing, dispensing and distribution of medicines. The main aim of PPMS is to facilitate rational use of medicines (RUM). There is paucity of published data analysing the effectiveness of PPMS. The present review has been done to assess the effectiveness of prescription pattern monitoring studies in promoting RUM. Data search was conducted on internet. A multitude of PPMS done on different classes of drugs were collected and analyzed. PPMS using WHO prescribing indicators were also included. The present article reviews various prescription pattern monitoring studies of drugs conducted all over country and abroad. It was observed in the majority of such studies that physicians do not adhere to the guidelines made by regulatory agencies leading to irrational use of medicines. This in turn leads to increased incidence of treatment failure, antimicrobial resistance and economic burden on the patient and the community as a whole. The treatment of diseases by the use of essential drugs, prescribed by their generic names, has been emphasized by the WHO and the National Health Policy of India. We conclude that the prescription monitoring studies provide a bridge between areas like rational use of drugs, pharmacovigilance, evidence based medicine, pharmacoeconomics, pharmacogenetics and ecopharmacovigilance. In India, this is the need of the hour to utilise the data generated by so many prescription pattern monitoring studies done in every state and on every drug, so that the main aim of promoting rational use of drugs is fulfilled.
Keywords: Drug auditing, drug utilization pattern, pharmacoepidemiology, prescription-monitoring, rational use of drugs
|How to cite this article:|
Jain S, Upadhyaya P, Goyal J, Abhijit K, Jain P, Seth V, Moghe VV. A systematic review of prescription pattern monitoring studies and their effectiveness in promoting rational use of medicines. Perspect Clin Res 2015;6:86-90
|How to cite this URL:|
Jain S, Upadhyaya P, Goyal J, Abhijit K, Jain P, Seth V, Moghe VV. A systematic review of prescription pattern monitoring studies and their effectiveness in promoting rational use of medicines. Perspect Clin Res [serial online] 2015 [cited 2020 Jun 5];6:86-90. Available from: http://www.picronline.org/text.asp?2015/6/2/86/154005
| Introduction|| |
Medicines are an integral part of the health care, and modern health care is impossible without the availability of necessary medicines. They not only save lives and promote health, but prevent epidemics and diseases too. Accessibility to medicines is the fundamental right of every person.  However, to bring optimal benefit, they should be safe, efficacious, cost-effective and rational.
Drug utilization research was defined by World Health Organization (WHO) in 1977 as a marketing, distribution, prescription, and use of drugs in society, with special emphasis on the resulting medical, social and economic consequences. Pharmacoepidemiology is the study of the use and effects/side-effects of drugs in large numbers of people with the purpose of supporting the rational and cost-effective use of drugs in the population thereby improving health outcomes. Drug utilization research is thus an essential part of pharmacoepidemiology as it describes the extent, nature and determinants of drug exposure. Over time, the distinction between these two terms has become less sharp, and they are sometimes used interchangeably. Together, drug utilization research and pharmacoepidemiology may provide insights into many aspects of drug use and drug-prescribing. They provide much useful information on indirect data on morbidity, treatment cost of illness, therapeutic compliance, incidence of adverse reactions, effectiveness of drug consumption and choice of comparators. 
Prescription pattern monitoring studies (PPMS) are drug utilization studies with the main focus on prescribing, dispensing and administering of drugs. They promote appropriate use of monitored drugs and reduction of abuse or misuse of monitored drugs. PPMS also guide and support prescribers, dispensers and the general public on appropriate use of drugs, collaborate and develop working relationship with other key organizations to achieve a rational use of drugs. Prescription Patterns explain the extent and profile of drug use, trends, quality of drugs, and compliance with regional, state or national guidelines like standard treatment guidelines, usage of drugs from essential medicine list and use of generic drugs. There is increasing importance of PPMS because of a boost in marketing of new drugs, variations in pattern of prescribing and consumption of drugs, growing concern about delayed adverse effects, cost of drugs and volume of prescription. 
The aim of PPMS is to facilitate the rational use of drugs in a population. Irrational use of medicines is a major problem worldwide. WHO estimates that more than half of all medicines are prescribed, dispensed or sold inappropriately, and that half of all patients fail to take them correctly. The overuse, underuse or misuse of medicines results in wastage of scarce resources and widespread health hazards. The rational use of medicines (RUM) is defined as "Patients receive medications appropriate to their clinical needs, in doses that meet their own individual requirements, for an adequate period of time, and at the lowest cost to them and their community. 
A large number of studies have been conducted to study the prescribing pattern of physicians across the country. The studies conclude the irrational prescribing practices of prescribers and suggest RUM at all levels of health care delivery system. However, no systematic reviews, meta-analyses, or randomized controlled trials are present about the relevance of PPMS in promoting rational use of drugs. The present review has been done to assess the effectiveness of PPMS in developing RUM. This study was conducted with the aim of analyzing the prescribing practices of physicians and to assess the extent to which the goal of RUM has been achieved. The drugs frequently prescribed by the physicians for disease conditions like diabetes, schizophrenia, hypertension, epilepsy, inflammatory conditions such as osteoarthritis have been included in this study. An effort has been made to also include the prescribing trends of antimicrobials due to the growing concern of antimicrobial resistance. Data search pertaining to assessment of PPMS was conducted on the internet. A plethora of information on the prescribing trends of physicians was available which has been summarized in this study.
| Prescription Pattern Monitoring Studies in India|| |
Prescription pattern monitoring of antidiabetic drugs
A prospective, cross-sectional study was carried out in medicine outpatient clinic of tertiary care hospital, Ahmedabad for 8 weeks. Patients with type-2 diabetes and on drug therapy for at least 1-month were included.  A similar study was undertaken to identify patterns of antidiabetic drugs prescribing in patients with established type 2 diabetes mellitus (T2DM) who attended the endocrinology Outpatient Clinic in Postgraduate Institute of Medical Education and Research, Chandigarh, India.  A prospective observational study was carried out for a period of 5 months in diabetic patients who visited the medicine outdoor department of a tertiary care teaching hospital in India to assess prescription pattern, cost of antidiabetic drugs and adherence to treatment guidelines.  All of these studies demonstrated that prescription pattern of antidiabetic drugs adhere to standard treatment guidelines.
Prescription pattern monitoring of antipsychotic drugs
The study was conducted in outpatients of the Department of Psychiatry, Chhatrapati Shahuji Maharaj Medical University, U.P., Lucknow.  Another study was conducted in which an audit of the prescription pattern of antipsychotic drugs in patients with schizophrenia, in a tertiary care center in India was performed.  A similar study was done in psychiatry outpatient clinic of a tertiary care hospital in India.  These studies concluded that the poly-pharmacy of antipsychotic drugs is common.
Prescription pattern monitoring of antiasthmatic drugs
A prescription-monitoring study was conducted to evaluate the drug-prescribing trend of antiasthmatic drugs in urban and rural areas of Saurashtra region, Gujarat.  Another drug utilization or prescription-monitoring study was conducted in various hospitals of Shamli, Prabuddha Nagar, Uttar Pradesh, India. The study was conducted in three famous hospitals of Shamli on 330 patients.  A similar prescription-monitoring study was conducted to establish the drug-prescribing trend of antiasthmatic drugs in various hospitals of Gorakhpur.  It is concluded that the prescribing pattern of antiasthmatics does not completely meet standard treatment guidelines.
Prescription pattern monitoring of antihypertensive drugs
A prescription based survey among patients with established hypertension was conducted at the Medicine Outpatient Department (OPD) of University Teaching Hospital in South Delhi, India. It was a prospective study aimed to investigate the use of antihypertensive drugs and to identify whether such pattern of prescription is appropriate in accordance with international guidelines for the management of hypertension.  A similar prospective observational study was carried out for a period of 6 months (January 2011-June 2011) in an OPD of Rohini Superspeciality Hospital, Warangal, Andhra Pradesh to assess the prescribing pattern for antihypertensives in geriatric patients.  Another cross-sectional study was carried out to evaluate the prescribing pattern of antihypertensive in T2DM patients and compare with existing recent guidelines in North India.  The above mentioned studies revealed that the antihypertensive utilization pattern is in accordance with the international guidelines for treatment of hypertension. There is considerable use of different antihypertensive drug combinations for the treatment of hypertension and such practice has a positive impact on the overall blood pressure control.
Prescription pattern monitoring of antiepileptic drugs
A prospective study was carried out between January and April 2011 in the Neurosciences Centre OPD at All India Institute of Medical Sciences, New Delhi to analyze prescription pattern and utilization behavior of antiepileptic drugs as well as analysis of quality of life data.  Another study was carried out in Cuttack to get an insight into the type of epileptic seizures and to assess the drug utilization pattern of antiepileptic drugs.  Another study conducted in India evaluated the utilization pattern of antiepileptic drugs in different hospitals.  All these studies concluded that the poly-pharmacy is commonly observed in prescribing antiepileptic drugs and is the cause of concern.
Prescription pattern monitoring of nonsteroidal antiinflammatory drugs
Nonsteroidal antiinflammatory drugs (NSAIDs) constitute one of the largest group of pharmaceutical agents used all over the world. They are also the most common drugs reported causing adverse drug reactions by drug regulatory agencies. Several studies have been conducted to study the prescription pattern of NSAIDS. A drug utilization study was conducted in the out-patient clinic of the orthopedics department from December 2002 to June 2003 in a tertiary care hospital in India to determine the quality of prescribing.  Another prospective study was conducted in Orthopedics OPD of a tertiary care teaching hospital in Dehradun to analyze the prescribing pattern of NSAIDS.  These studies suggest that the prescribing pattern of NSAIDs was not in accordance with current guidelines mentioned by regulatory agencies. Moreover, the adverse effect profile should be considered while prescribing these drugs.
Prescription pattern monitoring of antibiotics
Monitoring the antibiotic utilization pattern is of growing concern due to increase in antibiotic resistance, lack of adherence to standard treatment guidelines and rise in health care expenditure. Various studies have been conducted to assess the prescribing practices of medical practitioners in this context. A cross-sectional prospective study was carried out in six inpatient department (Surgery, Orthopedics, ENT, Ophthalmology, Medicine and Pediatrics) of a 550-bedded tertiary care hospital in Trivandrum to evaluate the prescribing pattern of antibiotics.  A similar study was conducted to analyze the current usage of antimicrobial agents in the Medical Intensive Care Unit of a teaching hospital in Central India.  Another study was done to assess the antibiotics usage in the pediatric population.  The survey was conducted at the outpatient facilities in the South 24 Parganas district of West Bengal. Data were collected prospectively by interviewing patients immediately after patient-physician and patient-dispenser encounters. A total of 312 prescriptions were analyzed.  A cross-sectional study was carried out to analyze and compare antibiotic prescribing for inpatients, in two private sector tertiary care hospitals; one teaching and one nonteaching in Ujjain.  All these studies concluded inappropriate use of antibiotics and lack of adherence to standard treatment guidelines resulting in increased incidence of antibiotic resistance.
How effective prescription pattern monitoring studies are in India?
A large number of PPMS have been done all over the world to determine the quality of prescribing practices of physicians and promote RUM. However, it has been observed in the majority of such studies that physicians do not adhere to the guidelines made by regulatory agencies leading to irrational use of medicines. This in turn leads to increase the incidence of treatment failure, antimicrobial resistance and economic burden on the patient and the community as a whole. The treatment of diseases by the use of essential drugs, prescribed by their generic names, has been emphasized by the WHO and the National Health Policy of India.  Essential medicines are those that satisfy the priority health care needs of the population. They are selected with due regard to public health relevance, evidence on efficacy and safety, and comparative cost-effectiveness. Essential medicines are intended to be available within the context of functioning health systems at all times in adequate amounts, in the appropriate dosage forms, with assured quality and adequate information, and at a price the individual and the community can afford.  The National List of Essential Medicines of India (NLEMI 2011) was revised recently by the Ministry of Health and Family Welfare, Government of India, in June 2011, nearly 8 years after the previous list, on the directions of the Supreme Court of India.  The list was accessed from the official website of the drug regulatory authority of India, the Central Drugs Standard Control Organization,  downloaded and reviewed by comparing it with the 17 th Model WHO EML, March 2011, the 3 rd WHO Model EML for children, March 2011 and the National EML 2003. 
In United States, drug utilization studies are primarily developed in the form of prescription drug monitoring program (PDMP) at institutional, state and national level. A PDMP is a tool that can be used to address prescription drug diversion and abuse. PDMPs serve multiple functions, including: Patient care tool; drug epidemic early warning system; and drug diversion and insurance fraud investigative tool. They help prescribers avoid drug interactions and identify drug-seeking behaviors or "doctor shopping."  In European countries, drug utilization research also describe and compare the patterns of specific groups of drugs.  In developing the country such as India, PPMS are done at individual level and not as a national program in contrast to developed countries. Hence, the data generated is not analyzed and used in promoting RUM.
A large number of socioeconomic factors affect drug utilization in India. Like; illiteracy, poverty, multiple health care systems, drug advertisement and promotions, sales without prescription, over the counter drugs etc.  Cost factors like prices of drug, entry of new drug in market, volume of drug use; Population factors like changes in total population, demographics, change in health status of a population; system factors like changes in health program and health system reforms and restructuring, shift of drug provision from hospital to community, changes in policies and program; research and technology related factors include new treatment approaches, drugs replacing surgery, availability of more diagnostic technologies, evidence-based curative approaches, use of newer pharmaceutical technology; practice and people related factors like changes in prescribing and dispensing, number and mix of prescribers, multiple doctoring, consumer expectations and behavior and wastage; pharmaceutical industry related factors like new drug products, promotion of drugs to physicians, drug sampling and consumer advertising. These factors present important challenges in developing the country such as India for development of indicators to monitor trends and results that affect the performance of health care system and health of the population. 
It is very important that the PPMS should be consultative and transparent, selection criteria be explicit, selection of the medicines be linked to evidence-based standard clinical guidelines, clinical guidelines and the list be divided into levels of care, and are regularly reviewed and updated. The effectiveness of PPMSs can be conceptualized in terms of their impact in ensuring the appropriate use of prescription controlled substances, reducing their diversion and abuse, and improving health outcomes, both at the patient and community levels. This impact is maximized when prescription history data are, to the extent technologically feasible, complete and accurate; analyzed appropriately and expeditiously; made available in a proactive and timely manner; disseminated in ways and formats that best serve the purposes of end users; and applied in all relevant domains by all appropriate users. This suggests that PPMSs can be thought of as information systems with inputs, internal operations, outputs, and customers who make use of their products. 
| Conclusion|| |
The PPMS are an ever evolving field. It compares observed patterns of drug use and current recommendations and guidelines. This study concludes the ineffectiveness of PPMS in developing RUM in India, and stringent measures should be taken to rectify it. Feedback should be provided to prescribers on the basis of data collected. How many prescribers actually utilize the data in clinical practice is questionable. The aim of PPMS is to produce rational prescribers rather than confused practitioners in the therapeutic jungle. Unless strict rules are formed by the regulatory authorities, it is difficult to modify or bring changes in the system. PPMS provide a bridge between areas like RUM, pharmacovigilance, evidence-based medicine, Pharmacoeconomics, Pharmacogenetics and Ecopharmacovigilance. In India, this is the need of the hour to utilize the data generated by so many PPMSs done in every state and on every drug so that the main aim of promoting rational use of drugs is fulfilled.
| References|| |
Kar SS, Pradhan HS, Mohanta GP. Concept of essential medicines and rational use in public health. Indian J Community Med 2010;35:10-3.
Promoting Rational Use of Medicines: Core Components-WHO Policy perspectives on medicine, No. 005, September 2002. In: Essential medicines and Health Products Information Portal. A World Health Organization Resource. Available from: http://www.apps.who.int/medicinedocs/en/d/Jh3011e/2.html
. [Last accessed on 2014 Apr 22].
Strom BL, Stephan EK, editors. Pharmacoepidemiology. 4 th
ed. Wiley-Blackwell: John Wiley and Sons, English; 2005.
Patel B, Oza B, Patel K, Malhotra S, Patel V. Pattern of antidiabetic drugs use in type-2 diabetic patients in a medicine outpatient clinic of a tertiary care teaching hospital. Int J Basic Clin Pharmacol 2013;2:485-91.
Dhanaraj E, Raval AD, Yadav R, Bhansali A, Tiwari P. Prescribing pattern of antidiabetic drugs and achievement of glycemic control in T2DM patients tertiary care hospital in North India. Int J Diabetes Dev Ctries 2013;33:140-6.
Acharya KG, Shah KN, Solanki ND, Rana DA. Evaluation of antidiabetic prescriptions, cost and adherence to treatment guidelines: A prospective, cross-sectional study at a tertiary care teaching hospital. J Basic Clin Pharm 2013;4:82-7.
Trivedi JK, Dhyani M, Yadav VS, Rai SB. Anti-psychotic drug prescription pattern for schizophrenia: Observation from a general hospital psychiatry unit. Indian J Psychiatry 2010;52:279.
Ramadas S, Kuttichira P, Sumesh TP, Ummer SA. A study of an antipsychotic prescription pattern of patients with schizophrenia in a developing country. Indian J Psychol Med 2010;32:13-6.
Grover S, Kumar V, Avasthi A, Kulhara P. An audit of first prescription of new patients attending a psychiatry walk-in-clinic in north India. Indian J Pharmacol 2012;44:319-25.
Patel PD, Patel RK, Patel NJ. Analysis of prescription pattern and drug utilization in asthma therapy. Int Res J Pharm 2012;3:257-60.
Srivastava R, Sharma S, Keshri L, Wal P. Assessment of prescription pattern in asthma therapy at Shamli hospitals. Rev Recent Clin Trials 2012;7:158-64.
Pandey A, Tripathi P, Pandey RD. Prescription pattern in asthma therapy at Gorakhpur hospitals. Lung India 2010;27:8-10.
Khurshid F, Aqil M, Alam MS, Kapur P, Pillai KK. Antihypertensive medication prescribing patterns in a university teaching hospital in South Delhi. Int J Pharm Sci Res 2012;3:2057-63.
Mohd AH, Mateti UV, Konuru V, Parmar MY, Kunduru BR. A study on prescribing patterns of antihypertensives in geriatric patients. Perspect Clin Res 2012;3:139-42.
Dhanaraj E, Raval A, Yadav R, Bhansali A, Tiwari P. Prescription pattern of antihypertensive agents in T2DM patients visiting tertiary care centre in North India. Int J Hypertens 2012;2012:520915.
Haroon A, Tripathi M, Khanam R, Vohora D. Antiepileptic drugs prescription utilization behavior and direct costs of treatment in a national hospital of India. Ann Indian Acad Neurol 2012;15:289-93.
Pal A, Prusty SK, Sahu PK, Swain T. Drug utilization pattern of antiepileptic drugs: A Pharmacoepidemiologic and Pharmavigilance study in a Tertiary Teaching Hospital in India. Asian J Pharm Clin Res 2011;4:96-9.
Pathak S, Singh L, Singh T, Sharma SK. Prescribing patterns of anti-epileptic drugs in different age group in India. J Drug Dis Ther 2013;1:69-75.
Gupta M, Malhotra S, Jain S, Aggarwal A, Pandhi P. Pattern of prescription of non-steroidal antiinflammatory drugs in orthopaedic outpatient clinic of a north Indian tertiary care hospital. Indian J Pharmacol 2005;37:404-5.
Sharma T, Dutta S, Dhasmana DC. Prescribing Pattern of NSAIDS in Orthopaedic OPD of a Tertiary Care Teaching Hospital in Uttaranchal. JK Sci 2006;8:160-2.
Remesh A, Salim S, Gayathri AM, Nair U, Retnavally KG. Antibiotics prescribing pattern in the in-patient departments of a tertiary care hospital. Arch Pharma Pract 2013;4:71-6.
Badar VA, Navale SB. Study of prescribing pattern of antimicrobial agents in medicine intensive care unit of a teaching hospital in Central India. J Assoc Physicians India 2012;60:20-3.
Viswanad V, Abraham S, Abraham A, Anupama PP, Muralidharan A, Arya SK. Confrontational use of antibiotics in pediatric prescriptions. Deccan J Pharm Cosmet 2010;1:52-6.
Hazra A, Tripathi SK, Alam MS. Prescribing and dispensing activities at the health facilities of a non-governmental organization. Natl Med J India 2000;13:177-82.
Sharma M, Eriksson B, Marrone G, Dhaneria S, Lundborg CS. Antibiotic prescribing in two private sector hospitals; one teaching and one non-teaching: A cross-sectional study in Ujjain, India. BMC Infect Dis 2012;12:155.
Kishore J. National Health Programs of India. 6 th
ed. New Delhi: Century Publications; 2006. p. 370.
Gama H. Drug utilisation studies. Arqui Med 2008;22:69-74.
Sathvik BS. Drug utilisation review/evaluation In: Parthasarath G, Nyfort-Hansen K, Nahata MC, editors. A Textbook of Clinical Pharmacy Practice. 1 st
ed. India: Orient Longman; 2004. p. 362-75.
Shalini S, Ravichandran V, Mohanty BK, Dhanaraj SK, Saraswathi R. Drug utilization studies - An overview. Inter J Pharmaceut Sci Nanotechnol 2010;31:803-10.
|This article has been cited by|
||Asian managemet of hypertension: Current status, home blood pressure, and specific concerns in India
| ||Guru Prasad Sogunuru,Surabhi Mishra |
| ||The Journal of Clinical Hypertension. 2020; |
|[Pubmed] | [DOI]|
||Factors Affecting Medicine-Induced Demand and Preventive Strategies: A Scoping Review
| ||Marita Mohammadshahi,Minoo Alipouri Sakha,Leila Zarei,Maryam Karimi,Farzad Peiravian |
| ||Shiraz E-Medical Journal. 2019; In Press(In Press) |
|[Pubmed] | [DOI]|
||The challenge of antimicrobial resistance: What economics can contribute
| ||Laurence S. J. Roope,Richard D. Smith,Koen B. Pouwels,James Buchanan,Lucy Abel,Peter Eibich,Christopher C. Butler,Pui San Tan,A. Sarah Walker,Julie V. Robotham,Sarah Wordsworth |
| ||Science. 2019; 364(6435): eaau4679 |
|[Pubmed] | [DOI]|
||Exploring the Impact of the Rational Antibiotic Use System on Hospital Performance: The Direct Effect and the Spillover Effect
| ||Shanshan Guo,Wenchao Du,Shuqing Chen,Xitong Guo,Xiaofeng Ju |
| ||International Journal of Environmental Research and Public Health. 2019; 16(18): 3463 |
|[Pubmed] | [DOI]|
||Assessment of prescription pattern and prescription error in outpatient Department at Tertiary Care District Hospital, Central Nepal
| ||Rajeev Shrestha,Srijana Prajapati |
| ||Journal of Pharmaceutical Policy and Practice. 2019; 12(1) |
|[Pubmed] | [DOI]|
||Temporal Trends and Factors Associated with Medication Prescription Patterns in Peritoneal Dialysis Patients
| ||Ludimila G. Campos,Jennifer Bragg-Gresham,Yun Han,Thyago P. Moraes,Ana E. Figueiredo,Pasqual Barretti,Rajesh Balkrishnan,Rajiv Saran,Roberto Pecoits-Filho |
| ||Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis. 2018; 38(4): 293 |
|[Pubmed] | [DOI]|
||Drug and therapeutics committees in Nigeria: evaluation of scope and functionality
| ||Joseph O. Fadare,Olayinka Ogunleye,Reginald Obiako,Samuel Orubu,Okezie Enwere,Adetutu A. Ajemigbitse,Johanna C. Meyer,Ehijie Enato,Amos Massele,Brian Godman,Lars L. Gustafsson |
| ||Expert Review of Clinical Pharmacology. 2018; 11(12): 1255 |
|[Pubmed] | [DOI]|
||Analgesic prescribing patterns of dental practitioners in Germany
| ||Frank Halling,Paul Heymann,Thomas Ziebart,Andreas Neff |
| ||Journal of Cranio-Maxillofacial Surgery. 2018; |
|[Pubmed] | [DOI]|
||Assessment of utilization pattern of fixed dose drug combinations in primary, secondary and tertiary healthcare centers in Nepal: a cross-sectional study
| ||Arjun Poudel,Mohamed Izham Mohamed Ibrahim,Pranaya Mishra,Subish Palaian |
| ||BMC Pharmacology and Toxicology. 2017; 18(1) |
|[Pubmed] | [DOI]|
||Monitoring prescribing patterns using regression and electronic health records
| ||Daniel Backenroth,Herbert S. Chase,Ying Wei,Carol Friedman |
| ||BMC Medical Informatics and Decision Making. 2017; 17(1) |
|[Pubmed] | [DOI]|
||Underuse of Methotrexate in the Treatment of Rheumatoid Arthritis: A National Analysis of Prescribing Practices in the US
| ||Melanie K. Rohr,Ted R. Mikuls,Stanley B. Cohen,J. Carter Thorne,James R. OĉDell |
| ||Arthritis Care & Research. 2017; |
|[Pubmed] | [DOI]|
||A review on prescribing patterns of antihypertensive drugs
| ||Noah Jarari,Narasinga Rao,Jagannadha Rao Peela,Khaled A. Ellafi,Srikumar Shakila,Abdul R. Said,Nagaraja Kumari Nelapalli,Yupa Min,Kin Darli Tun,Syed Ibrahim Jamallulail,Avinash Kousik Rawal,Ranjani Ramanujam,Ramesh Naidu Yedla,Dhilip Kumar Kandregula,Anuradha Argi,Laxmi Teja Peela |
| ||Clinical Hypertension. 2015; 22(1) |
|[Pubmed] | [DOI]|