Year : 2018 | Volume
: 9 | Issue : 2 | Page : 70--75
An analysis of adverse drug reactions in extremes of age group at tertiary care teaching hospital
Saloni Amin1, Samidh Shah1, Mira Desai1, Asha Shah2, KM Maheriya3
1 Department of Pharmacology, B. J. Medical College, Ahmedabad, Gujarat, India
2 Department of Medicine, B. J. Medical College, Ahmedabad, Gujarat, India
3 Department of Paediatrics, B. J. Medical College, Ahmedabad, Gujarat, India
Objectives: To analyze clinical spectrum, seriousness, outcome, causality, severity and preventability of ADRs in geriatrics and pediatric patients.
Materials and Methods: All ADRs reported in geriatrics (≥ 65 years) and pediatrics (≤ 12 years) indoor as well outdoor patients from January, 2010 to April, 2016 at ADR monitoring centre, Department of Pharmacology, B. J. Medical College and Civil Hospital were identified. A retrospective analysis was carried out for clinical presentation, causality (as per WHO-UMC scale and Naranjo's algorithm), severity (Hatwig and Seigel scale) and preventability (Schaumock and Thornton criteria).
Results: Out of 3690 ADRs, 160 were in geriatric patients (4.33%) while 231 in pediatric patients (6.26%). The most commonly affected body system was gastrointestinal (53, 33.13%) followed by neurological disorders (26, 16.25%) in geriatric patients. While in pediatric patients, the most commonly affected body system was skin and appendages (73, 31.60 %) followed by gastrointestinal disorders (58, 25.11%). The most common causal drugs in geriatric patients was cardiovascular (38, 23.75%) followed by antimicrobials (28, 13.25%). While in pediatric patients, the most common causal drug group was antimicrobials (85, 33.46%) followed by blood products (36, 14.12%). Total 17 ADRs reported following vaccination, 7 (41.17%) were injection site abscess and 11 (64.70%) were due to pentavalent vaccine. Polypharmacy was common in geriatrics (31, 19.37%). Causality assessment for majority of ADRs in geriatrics (83, 52.5%) and pediatrics (171, 67.32%) were probable.
Conclusion: ADRs are common in geriatric and pediatric patients usually within four weeks of oral therapy. Active surveillance of drug safety monitoring in these vulnerable population is recommended.
Dr. Samidh Shah
Department of Pharmacology, B. J. Medical College, Ahmedabad - 380 016, Gujarat
|How to cite this article:|
Amin S, Shah S, Desai M, Shah A, Maheriya K M. An analysis of adverse drug reactions in extremes of age group at tertiary care teaching hospital.Perspect Clin Res 2018;9:70-75
|How to cite this URL:|
Amin S, Shah S, Desai M, Shah A, Maheriya K M. An analysis of adverse drug reactions in extremes of age group at tertiary care teaching hospital. Perspect Clin Res [serial online] 2018 [cited 2019 Oct 22 ];9:70-75
Available from: http://www.picronline.org/article.asp?issn=2229-3485;year=2018;volume=9;issue=2;spage=70;epage=75;aulast=Amin;type=0