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  Indian J Med Microbiol
 

Figure 3 :Decision model for phase 0 clinical trial and further clinical development. (PK+, desired plasma drug levels are achieved; PD+, target modulation is observed) (Adapted with permission from S. Kummar, J.H. Doroshow et al. Phase 0 clinical trials: Recommendations from the task force on methodology for the development of innovative cancer therapies. Eur J Can 2009;45:741-746.)

Figure 3 :Decision model for phase 0 clinical trial and further clinical development. (PK+, desired plasma drug levels are achieved; PD+, target modulation is observed) (Adapted with permission from S. Kummar, J.H. Doroshow et al. Phase 0 clinical trials: Recommendations from the task force on methodology for the development of innovative cancer therapies. Eur J Can 2009;45:741-746.)