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Year : 2014  |  Volume : 5  |  Issue : 4  |  Page : 167-171

Effect of vitamin D3 on mild to moderate persistent asthmatic patients: A randomized controlled pilot study

1 Department of Pulmonary Medicine, SRM Medical College Hospital and Research Centre, Porur, India
2 Department of Pharmacy Practice, Faculty of Pharmacy, Sri Ramachandra University, Porur, India
3 Doctor of Pharmacy, SRM College of Pharmacy, SRM University, Kattankulathur, Kanchipuram Dt, Tamil Nadu, India

Correspondence Address:
A D Nageswari
Department of Pulmonary Medicine, SRM Medical College Hospital and Research Center, SRM University, Kattankulathur, Kanchipuram - 603 203, Tamil Nadu
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/2229-3485.140556

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Background: Asthma is a common chronic inflammatory disease of the bronchial airways. Well defined treatment options for asthma are very few. The role of vitamin D 3 on asthma is still baffling. Aim: We have examined the effect of vitamin D 3 supplementation in mild to moderate persistent asthma patients. Materials and Methods: We conducted an open labeled, randomized comparative trial in 48 asthma patients. The study duration was about 90 days. The study had a run-in-period of 2 weeks. At the end of run-in-period, patients were divided into two groups: Usual care group (n = 31) patients received budesonide and formoterol and intervention care group (n = 32) patients received vitamin D 3 supplementation along with their regular medicine. Results: The primary outcome of the study was to measure the improvement in forced expiratory volume in 1 second (FEV 1 ). Patients in both groups had a significant improvement in FEV 1 at the end of the study. The mean difference in percentage predicted FEV 1 in usual care and intervention care group was 4.95 and 7.07 respectively. Conclusion: The study concluded that adjunctive therapy of vitamin D 3 is effective in asthma patients. The present study will be an evidence based report; however, future studies are warranted in longer duration of time to substantiate the present findings.

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