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Year : 2014  |  Volume : 5  |  Issue : 4  |  Page : 190-194

Comparative evaluation of aliskiren, ramipril, and losartan on psychomotor performance in healthy volunteers: A preliminary report

1 Department of Pharmacology and Therapeutics, Government Medical College, Jammu (Jammu and Kashmir), India
2 Department of Medicine, Government Medical College, Jammu (Jammu and Kashmir), India

Correspondence Address:
Vijay Khajuria
Department of Pharmacology, Government Medical College, Jammu (Jammu and Kashmir)
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/2229-3485.140564

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Aim: To compare the effects of aliskiren, ramipril, and losartan on the psychomotor performance in healthy volunteers. Materials and Methods: In this preliminary, single-dose, open-label, cross-over study conducted in 12 healthy volunteers, psychomotor assessment was carried out by four tests: Simple reaction time (SRT), multiple choice reaction time test (MCRT), critical flicker fusion frequency threshold test (CFFT), and tracking performance test (TPT). Each volunteer received a single dose of each of the three test drugs with a washout period of 10 days between different test sessions and then evaluated for post-drug scores at 2-h intervals up to 12 h and then at 24 h. The changes from the baseline scores by the test drug were statistically analyzed. Results: All the three antihypertensive drugs caused significant improvement in a similar fashion on SRT, MCRT calculated as error index, CFFT, and TPT. Aliskiren caused numerically more improvement than the other two test drugs, suggesting better cognitive profile. However, inter-drug comparisons were nonsignificant. Conclusion: The results of the study highlight improvement of the cognitive functions equally by ramipril, losartan, and aliskiren. The results of the study could be of immense clinical utility in ambulatory hypertensive patients especially engaged in sensory-motor coordination tasks like driving and operating on mechanical tools.

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