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REVIEW ARTICLE
Year : 2021  |  Volume : 12  |  Issue : 2  |  Page : 66-71

The changing perspective of clinical trial designs


1 Department of Geriatric Medicine, AIIMS, New Delhi, India
2 Department of Biostatistics, AIIMS, New Delhi, India

Correspondence Address:
Dr. Sunny Singhal
Department of Geriatric Medicine, Room No. 3095A, Third Floor, Academics Block, AIIMS, Ansari Nagar, New Delhi
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/picr.PICR_138_20

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Maintaining health and well-being of the population is a universal priority. Governments around the globe are therefore seeking greater efficiency and better outcomes from researches being held. Although large randomized trials or systematic review of several large trials provides the highest level of evidence, the intricate cost, time, and difficulties of conventional trials have led to questions about their sustainability commanding search for alternative approaches. Demands for improved competences in medical research have led to mounting interest in newer clinical trial designs. This article provides an insight into newer clinical trial designs, including cluster trials, adaptive designs, the master protocols along with their strengths, weaknesses, and which trials design should be opted for in different clinical scenarios.


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