Perspectives in Clinical Research

ORIGINAL ARTICLE
Year
: 2012  |  Volume : 3  |  Issue : 2  |  Page : 62--65

Health outcome and safety assessment of a fixed dose combination of Amantadine, Paracetamol, Chlorpheniramine maleate, and Phenylephrine introduction in India: A prescription event monitoring study


K Krishnaprasad, P Manshani, J Karankumar 
 Glenmark Pharmaceuticals Ltd, Corporate Enclave, Mumbai, India

Correspondence Address:
K Krishnaprasad
Glenmark Pharmaceuticals Ltd., Corporate Enclave, 3rd Floor, BD Sawant Marg, Chakala, Andheri (E), Mumbai - 400 099
India

To assess the likely impact of a fixed dose combination (FDC) of Amantadine, Paracetamol, Chlorpheniramine maleate, and Phenylephrine on the health outcome and safety profile arising from the complementary action of amantadine and other ingredients, we conducted a Prescription Event Monitoring study for patients with suspected Influenza symptoms who were prescribed this FDC in «SQ»real life clinical settings«SQ» or clinical practice. Between August 2010 and March 2011, Questionnaires were sent to doctors who provided data on the health outcome or safety profile. Sedation and allergy, including rash, were noted in few of the patients. None of the patients reported any major events. Most of the patients (60%) were initiated on FDC therapy within the first 24 hours of symptom onset. Even as a significant proportion of the patients (24.9%) had a concurrent history of allergy / rhinitis including asthma, few of them (4.1%) reported lack of improvement and had to be complemented with antibiotics. The FDC of Amantadine, Chlorpheniramine, Paracetamol, and Phenylephrine was found to be safe and well-tolerated when administered to patients within the first 24 to 48 hours of symptom onset.


How to cite this article:
Krishnaprasad K, Manshani P, Karankumar J. Health outcome and safety assessment of a fixed dose combination of Amantadine, Paracetamol, Chlorpheniramine maleate, and Phenylephrine introduction in India: A prescription event monitoring study.Perspect Clin Res 2012;3:62-65


How to cite this URL:
Krishnaprasad K, Manshani P, Karankumar J. Health outcome and safety assessment of a fixed dose combination of Amantadine, Paracetamol, Chlorpheniramine maleate, and Phenylephrine introduction in India: A prescription event monitoring study. Perspect Clin Res [serial online] 2012 [cited 2020 Nov 30 ];3:62-65
Available from: https://www.picronline.org/article.asp?issn=2229-3485;year=2012;volume=3;issue=2;spage=62;epage=65;aulast=Krishnaprasad;type=0