Perspectives in Clinical Research

ORIGINAL ARTICLE
Year
: 2014  |  Volume : 5  |  Issue : 1  |  Page : 16--19

Revised National Tuberculosis Control Program regimens with and without directly observed treatment, short-course: A comparative study of therapeutic cure rate and adverse reactions


Rengaraj Sivaraj1, Sivaraj Umarani2, Subramani Parasuraman3, Pyapti Muralidhar1 
1 Division of Pharmacology, Rajah Muthiah Medical College, Annamalai University, Chidambaram, Tamil Nadu, India
2 Division of Anatomy, Rajah Muthiah Medical College, Annamalai University, Chidambaram, Tamil Nadu, India
3 Pharmacology Unit, Faculty of Pharmacy, Asian Institute of Medicine, Science and Technology (AIMST) University, Bedong, Kedah, Malaysia

Correspondence Address:
Rengaraj Sivaraj
Division of Pharmacology, Rajah Muthiah Medical College, Annamalai University, Annamalai Nagar, Chidambaram - 608 002, Tamil Nadu
India

Objective: To compare the therapeutic cure rate and adverse reactions in the regimens of the Revised National Tuberculosis Control Program (RNTCP) with directly observed treatment, short-course (DOTS) and without DOTS. Materials and Methods: Fifty patients in the DOTS regimen and 50 patients in the non-DOTS regimen were enrolled in the study. All the participants were asked to come regularly for 3 consecutive days for sputum collection, and the sputum samples were examined for acid-fast bacilli. If tuberculosis (TB) was confirmed, the disease status was confirmed through a chest X-ray (PA view). The participants were monitored for adverse events arising from the use of anti-TB drugs for the next 6 months. Results: The TB cure rates for RNTCP with DOTS and RNTCP with non-DOTS were 80% and 66%, respectively. The DOTS therapy had a better cure rate for radiologically positive, sputum-positive cases compared with the non-DOTS regimen group. The non-DOTS treatment regimen had significantly increased numbers of adverse events in the hepatic and hematinic systems. Conclusion: The DOTS regimen has higher cure rates and a lower incidence of adverse reactions compared with the non-DOTS regimen.


How to cite this article:
Sivaraj R, Umarani S, Parasuraman S, Muralidhar P. Revised National Tuberculosis Control Program regimens with and without directly observed treatment, short-course: A comparative study of therapeutic cure rate and adverse reactions.Perspect Clin Res 2014;5:16-19


How to cite this URL:
Sivaraj R, Umarani S, Parasuraman S, Muralidhar P. Revised National Tuberculosis Control Program regimens with and without directly observed treatment, short-course: A comparative study of therapeutic cure rate and adverse reactions. Perspect Clin Res [serial online] 2014 [cited 2022 May 26 ];5:16-19
Available from: https://www.picronline.org/article.asp?issn=2229-3485;year=2014;volume=5;issue=1;spage=16;epage=19;aulast=Sivaraj;type=0